{"id":"W2016820377","doi":"10.1111/1440-1681.12195","title":"Monte Carlo simulation analysis of ceftobiprole, dalbavancin, daptomycin, tigecycline, linezolid and vancomycin pharmacodynamics against intensive care unit‐isolated methicillin‐resistant <i>Staphylococcus aureus</i>","year":2013,"lang":"en","type":"article","venue":"Clinical and Experimental Pharmacology and Physiology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Achaogen; Bayer Canada; AstraZeneca","keywords":"Daptomycin; Dalbavancin; Tigecycline; Linezolid; Vancomycin; Medicine; Pharmacodynamics; Methicillin-resistant Staphylococcus aureus; Pharmacology; Staphylococcus aureus; Pharmacokinetics; Antibiotics; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009134576,0.0003777686,0.0007290242,0.0005342567,0.0003661303,0.0005296052,0.000579038,0.0008170534,0.001389201],"category_scores_gemma":[0.003178011,0.0003270697,0.0008007247,0.0004954389,0.0003323013,0.0002947792,0.0002155183,0.000549287,0.000110372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009837938,"about_ca_system_score_gemma":0.001416184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02342738,"about_ca_topic_score_gemma":0.01202336,"domain_scores_codex":[0.9996749,0.000167131,0.00001263849,0.00003860865,0.0000538957,0.0000528814],"domain_scores_gemma":[0.9956608,0.003518193,0.0003058141,0.0000968036,0.0003195843,0.00009865754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006764332,0.00002574078,0.001369284,0.00001728146,0.00002885462,0.00002655732,0.00001138958,0.9963457,0.000357741,0.0008576713,0.00007334914,0.0008189008],"study_design_scores_gemma":[0.00001504006,0.00003759819,0.0004801367,0.000003908905,0.00001434113,0.00001220245,0.000006979484,0.9988012,0.0002447334,0.0002579153,0.0001212202,0.000004744006],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9350316,0.0008379677,0.05536054,0.0003928491,0.00004295788,0.0001167549,0.0005118892,0.0001774564,0.007527956],"genre_scores_gemma":[0.9895458,0.0002239196,0.008652369,0.00006107703,0.000008531632,0.0001371764,0.0002907363,0.00001350331,0.00106699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02342738,"threshold_uncertainty_score":0.04658204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02879991496707481,"score_gpt":0.3788203847657404,"score_spread":0.3500204697986656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}