{"id":"W2016836075","doi":"10.1016/j.vaccine.2015.02.055","title":"Outer membrane proteins preferentially load MHC class II peptides: Implications for a Chlamydia trachomatis T cell vaccine","year":2015,"lang":"en","type":"article","venue":"Vaccine","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Centre for Disease Control; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Health Canada; National Institutes of Health; Canada Research Chairs","keywords":"Chlamydia trachomatis; Biology; Epitope; Antigen; MHC class I; MHC class II; Virology; Major histocompatibility complex; Bacterial outer membrane; T cell; Microbiology; Chlamydiaceae; Molecular biology; Immune system; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006816448,0.0002986426,0.0004344935,0.0002573516,0.0003963048,0.00004222371,0.0004196207,0.0002999602,0.0006580775],"category_scores_gemma":[0.0005451243,0.000254526,0.0001616567,0.0003762679,0.00002499299,0.000286555,0.0001735786,0.0004499223,0.000858494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002198528,"about_ca_system_score_gemma":0.0003812336,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002137109,"about_ca_topic_score_gemma":0.000303996,"domain_scores_codex":[0.9979287,0.0001713788,0.0005243043,0.0006908649,0.00007863707,0.0006061204],"domain_scores_gemma":[0.9975923,0.0001601002,0.0001846902,0.0009973113,0.0009679794,0.00009760776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006713755,0.001397213,0.007153932,0.000104931,0.0003118521,9.992126e-7,0.0007170161,0.00005270785,0.9236078,0.0007321392,0.05832513,0.006924908],"study_design_scores_gemma":[0.01088159,0.001507919,0.1324871,0.00004144394,0.0001901882,0.0001568674,0.0001479828,0.00002246945,0.5502397,0.001197373,0.3025467,0.0005806576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784331,0.001249211,0.004292022,0.005572789,0.0006601162,0.003622164,0.0002231225,0.0003088184,0.005638666],"genre_scores_gemma":[0.97107,0.00007075039,0.001018119,0.00007834427,0.0002442881,0.00136351,0.0003577851,0.00005879018,0.02573841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3733681,"threshold_uncertainty_score":0.9999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03950231541175601,"score_gpt":0.3005460496239941,"score_spread":0.261043734212238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}