{"id":"W2016848332","doi":"10.1074/jbc.m308268200","title":"The Conserved Glutamate Residue Adjacent to the Walker-B Motif Is the Catalytic Base for ATP Hydrolysis in the ATP-binding Cassette Transporter BmrA","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"ATP-binding cassette transporter; Nucleotide; ATP hydrolysis; Biochemistry; Mutant; Residue (chemistry); Walker motifs; ATPase; Chemistry; Stereochemistry; Vanadate; Transporter; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002312073,0.0002316655,0.0004066433,0.00002116058,0.0003464643,0.00005068841,0.0005591218,0.0001772075,0.00009102259],"category_scores_gemma":[0.000238609,0.00007551791,0.000468064,0.000261885,0.0001787866,0.00002849171,0.00001251659,0.0006441439,0.000005424364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007920212,"about_ca_system_score_gemma":0.0001096491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007683156,"about_ca_topic_score_gemma":0.0000228886,"domain_scores_codex":[0.9981372,0.00009572251,0.000709817,0.0002314774,0.0003880599,0.0004377325],"domain_scores_gemma":[0.9984199,0.0005896146,0.0002835829,0.0004552749,0.0001114151,0.0001402338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005661911,0.001081122,0.03233319,0.0005385454,0.001116235,0.001889827,0.01005336,0.0002236142,0.9300055,0.0002834224,0.01393111,0.002882193],"study_design_scores_gemma":[0.004064095,0.0005245238,0.02274214,0.0004926961,0.0008464907,0.001099833,0.008801574,0.0001677083,0.7980199,0.0007016795,0.1620931,0.0004462484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9424434,0.0009174093,0.0001874882,0.05547507,0.0001205974,0.0004919544,0.00004034714,0.000008519652,0.0003151884],"genre_scores_gemma":[0.9953488,0.0003112652,0.0001346503,0.003278422,0.0002008488,0.00003628155,0.00001240735,0.00001521774,0.000662171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.148162,"threshold_uncertainty_score":0.3079531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03124530829647465,"score_gpt":0.2628030859234608,"score_spread":0.2315577776269861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}