{"id":"W2016879820","doi":"10.1080/01635581.2014.951733","title":"Flavonoid-Enriched Apple Fraction AF4 Induces Cell Cycle Arrest, DNA Topoisomerase II Inhibition, and Apoptosis in Human Liver Cancer HepG2 Cells","year":2014,"lang":"en","type":"article","venue":"Nutrition and Cancer","topic":"Garlic and Onion Studies","field":"Agricultural and Biological Sciences","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Apoptosis; Cell cycle; Flavonoid; Topoisomerase; Sorafenib; Cancer cell; Cell cycle checkpoint; Viability assay; Pharmacology; Cell growth; Hepatocellular carcinoma; Biology; Cancer research; Chemistry; Biochemistry; In vitro; Cancer; Antioxidant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004674576,0.0003393081,0.0001698219,0.0002918833,0.0001432215,0.0001099678,0.00005693777,0.0001258831,0.0008659278],"category_scores_gemma":[0.00004986467,0.00007291689,0.0001944433,0.0001282502,0.00007497417,0.00009393211,0.0000887908,0.0001696579,0.0001414791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001019827,"about_ca_system_score_gemma":0.0001162115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007361938,"about_ca_topic_score_gemma":0.001255482,"domain_scores_codex":[0.9999701,0.000005973402,0.000002797716,0.000007377166,0.000007106428,0.000006642746],"domain_scores_gemma":[0.9999799,0.000003919158,0.000005231409,0.000002102782,0.000004167241,0.000004661231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001393142,0.00002712458,0.0002263839,0.00005018843,0.00000748562,0.00004168495,0.00001091659,0.00002923456,0.9980506,0.00001336284,0.00002886609,0.001374888],"study_design_scores_gemma":[0.00003314373,0.0008881026,0.01973967,0.00001073634,0.00004304702,0.0004316366,0.00004016834,0.0003403512,0.9760299,0.00003780569,0.002399836,0.000005583289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947747,0.003134771,0.0007427188,0.00004700721,0.00001672874,0.00001843752,0.0002522103,0.00003129949,0.0009821472],"genre_scores_gemma":[0.9945963,0.001450865,0.001117462,0.000043929,0.00001044739,0.00001763053,0.0006641652,0.000008137713,0.002090985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008659278,"threshold_uncertainty_score":0.002896845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01522007557832051,"score_gpt":0.2371027299634775,"score_spread":0.221882654385157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}