{"id":"W2016906176","doi":"10.1192/bjp.178.5.448","title":"Effects of rapid tryptophan depletion on brain 5-HT<sub>2</sub>receptors: a PET study","year":2001,"lang":"en","type":"article","venue":"The British Journal of Psychiatry","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF; Schizophrenia Society of Ontario; University of British Columbia","funders":"Medical Research Council; Medical Research Council Canada; Canadian Psychiatric Research Foundation","keywords":"Tryptophan; Serotonin; Receptor; 5-HT receptor; Antidepressant; Endocrinology; Internal medicine; Chemistry; Positron emission tomography; Mood; Psychology; Pharmacology; Amino acid; Neuroscience; Medicine; Biochemistry; Psychiatry; Hippocampus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007832251,0.0002674902,0.0004506818,0.0001993583,0.0003804563,0.0002177744,0.0009262291,0.00006280571,0.00008837911],"category_scores_gemma":[0.0004878462,0.0002404468,0.0003379545,0.0006099631,0.0002079342,0.0003506804,0.00004459609,0.0008454291,0.00005424533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004666723,"about_ca_system_score_gemma":0.0001120329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002622229,"about_ca_topic_score_gemma":0.00004372907,"domain_scores_codex":[0.996229,0.001105814,0.0008741337,0.0003743182,0.001005199,0.0004115405],"domain_scores_gemma":[0.9980474,0.0005912703,0.0007359569,0.0003413541,0.0001022758,0.0001817537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000596004,0.003500547,0.008350597,0.00006962238,0.00003412465,0.001073704,0.0004074296,0.00002775768,0.9201626,0.00006210129,0.007627737,0.05808784],"study_design_scores_gemma":[0.008791947,0.008100264,0.1850732,0.001656887,0.0002817127,0.01997791,0.0005584966,0.00000893226,0.7722005,0.001150543,0.001506248,0.0006933574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933964,0.0003214261,0.00006152682,0.002100626,0.003169472,0.0007997629,0.00000738125,0.00004152983,0.0001018523],"genre_scores_gemma":[0.9966258,0.0004483655,0.0001007248,0.002184125,0.000524111,0.00002172975,3.502967e-7,0.0000593457,0.00003539907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1767226,"threshold_uncertainty_score":0.9805135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292136314145549,"score_gpt":0.2589665727511113,"score_spread":0.2460452096096558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}