{"id":"W2016921243","doi":"10.1371/journal.pone.0045993","title":"Differential Regulation of Breast Cancer-Associated Genes by Progesterone Receptor Isoforms PRA and PRB in a New Bi-Inducible Breast Cancer Cell Line","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut Gustave-Roussy; University of Agriculture, Faisalabad; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Université Laval","keywords":"Biology; Progesterone receptor; Breast cancer; Cancer research; Carcinogenesis; Amphiregulin; Regulation of gene expression; Endocrinology; Internal medicine; Estrogen receptor; Cancer; Epidermal growth factor receptor; Gene; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029374,0.0002411024,0.0003702683,0.000379112,0.0002696282,0.0004079173,0.0003136317,0.0002295931,0.001493504],"category_scores_gemma":[0.0001507848,0.0002221186,0.0002801095,0.0005963779,0.0001742515,0.0001750757,0.0002540202,0.0008228724,0.0008754451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002396928,"about_ca_system_score_gemma":0.0002587356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00139527,"about_ca_topic_score_gemma":0.002548168,"domain_scores_codex":[0.9994082,0.00005888028,0.00008541544,0.0001349151,0.0002449392,0.00006758671],"domain_scores_gemma":[0.9997734,0.00003162229,0.0000377608,0.00006454523,0.00005234539,0.00004024107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008974203,0.00004121373,0.000282432,0.00002120621,0.000004468628,0.00003108357,0.00002091499,0.00004978456,0.9983562,0.00007910113,0.00009242781,0.000931473],"study_design_scores_gemma":[0.00004495611,0.0004551405,0.01290761,0.000006266394,0.00004541353,0.0006493866,0.0000567327,0.002866007,0.9692305,0.00006626915,0.01365446,0.00001718736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9645897,0.002728748,0.01863175,0.0004518711,0.0001341941,0.0002052115,0.009061899,0.0004348797,0.003761869],"genre_scores_gemma":[0.9250988,0.002528964,0.02727581,0.0003214181,0.00005970824,0.000434781,0.02403346,0.0001752401,0.02007195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493504,"threshold_uncertainty_score":0.0049963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012106578553096,"score_gpt":0.2218593505442515,"score_spread":0.2097527719911555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}