{"id":"W2016923091","doi":"10.1038/nature12362","title":"Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells","year":2013,"lang":"en","type":"article","venue":"Nature","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":882,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"DNA demethylation; DNA methylation; Epigenetics; Biology; Molecular biology; 5-Hydroxymethylcytosine; Demethylation; Methylation; Chemistry; DNA; Gene; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000322914,0.0002623159,0.0003801702,0.0005572546,0.0002747238,0.0004324261,0.0003800552,0.0004215623,0.002008604],"category_scores_gemma":[0.0003626502,0.0002805879,0.0003568048,0.0002669023,0.0003599852,0.0002113099,0.0003478263,0.000707004,0.0005408035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006000497,"about_ca_system_score_gemma":0.0003562633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0022056,"about_ca_topic_score_gemma":0.003238156,"domain_scores_codex":[0.9997793,0.00004398233,0.00003531984,0.00005117985,0.00005165712,0.00003863678],"domain_scores_gemma":[0.9996104,0.0001318716,0.00004785427,0.000098199,0.00004999931,0.00006167965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001883755,0.00001007068,0.0001398264,0.00002179246,0.00001036891,0.00007292135,0.00001986933,0.00003868143,0.9983988,0.0001492179,0.00005045375,0.0008995418],"study_design_scores_gemma":[0.00001203994,0.0000500112,0.002045681,0.000003247453,0.00001014316,0.00008862132,0.00001370683,0.0001203033,0.9961191,0.00005319768,0.001480731,0.000003281074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791883,0.003939007,0.007288609,0.0003176299,0.0001030327,0.00006913525,0.00201725,0.0004508311,0.00662615],"genre_scores_gemma":[0.986286,0.0008010938,0.00217972,0.00008950377,0.00001397487,0.0000308519,0.001415476,0.00008609629,0.009097319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0022056,"threshold_uncertainty_score":0.00671947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00455691203124772,"score_gpt":0.2320055858160686,"score_spread":0.2274486737848209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}