{"id":"W2017017064","doi":"10.1371/journal.pbio.1000329","title":"Evolutionary Tinkering with Conserved Components of a Transcriptional Regulatory Network","year":2010,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"National Research Council Canada; Canadian Institutes of Health Research; Broad Institute","keywords":"Biology; Transcription factor; Genetics; Regulon; Transcriptional regulation; Regulation of gene expression; Gene; Ribosomal protein; General transcription factor; Gene regulatory network; Promoter; Gene expression; Computational biology; Cell biology; Ribosome; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005314226,0.0001652352,0.0003861252,0.000607323,0.0004690418,0.0007421216,0.000640001,0.000399297,0.001010394],"category_scores_gemma":[0.0008892225,0.000305296,0.0001973645,0.0006439709,0.0009945699,0.001058762,0.000748662,0.000670316,0.0002748074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004910356,"about_ca_system_score_gemma":0.0003196244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005900147,"about_ca_topic_score_gemma":0.0008651229,"domain_scores_codex":[0.9993846,0.00009226088,0.00002698272,0.0003265042,0.00008772561,0.00008197711],"domain_scores_gemma":[0.9994919,0.0001006743,0.0001196979,0.0001521722,0.00006480265,0.00007061011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003579966,0.00009063162,0.04364804,0.0002366928,0.0002233887,0.0006295667,0.00105831,0.003359347,0.8442354,0.01528188,0.0002510219,0.09062768],"study_design_scores_gemma":[0.0000993106,0.0006085421,0.7869705,0.0001328035,0.0004522366,0.005372553,0.001942583,0.03515349,0.07988269,0.03943338,0.04983262,0.0001193699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751609,0.001604291,0.0188966,0.0003229509,0.00001506025,0.000021288,0.000127774,0.0001421749,0.003708845],"genre_scores_gemma":[0.9862266,0.001019478,0.01082684,0.000153929,0.0000209413,0.0000236656,0.000362568,0.00004416536,0.001321785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010394,"threshold_uncertainty_score":0.003562748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887108704889512,"score_gpt":0.2386000500235614,"score_spread":0.2197289629746663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}