{"id":"W2017028093","doi":"10.1371/journal.pmed.1000315","title":"Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma","year":2010,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; University of British Columbia; Vancouver General Hospital; Canadian Centre for Applied Research in Cancer Control; Princess Margaret Cancer Centre; BC Cancer Agency","funders":"National Cancer Institute; Canadian Institutes of Health Research; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"Biology; Cancer research; Gene knockdown; Lung cancer; Adenocarcinoma; RNA interference; Ectopic expression; Cancer; Gene; RNA; Genetics; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001667393,0.0003126249,0.0006342315,0.0004576637,0.0000874345,0.000017035,0.0001571744,0.0001388977,0.001301391],"category_scores_gemma":[0.000238158,0.0002135659,0.0001080033,0.0005263216,0.0001827109,0.00009187114,0.00004369338,0.0005827189,0.0001172652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003132758,"about_ca_system_score_gemma":0.000318943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001677377,"about_ca_topic_score_gemma":0.0007692195,"domain_scores_codex":[0.9981627,0.0000331124,0.0005439661,0.0004943666,0.0004124637,0.0003533319],"domain_scores_gemma":[0.9986038,0.0002202871,0.0001643419,0.0005002404,0.0002225327,0.0002887899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001945874,0.001149334,0.064631,0.000135006,0.0001424697,0.000398139,0.005949224,0.000008967103,0.9234556,0.0001021651,0.003216375,0.0006171517],"study_design_scores_gemma":[0.03621536,0.002799402,0.5810663,0.000731962,0.003925635,0.0003960653,0.008156583,0.002766799,0.3483952,0.000149256,0.01449218,0.0009052244],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748031,0.002739299,0.0001941181,0.001410408,0.0005586745,0.0008189507,0.00002941168,0.00006175097,0.01938421],"genre_scores_gemma":[0.9929296,0.0001097132,0.0009471576,0.0005853677,0.0008569916,0.0001030076,0.0002060385,0.00005177699,0.004210326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5750604,"threshold_uncertainty_score":0.9996116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04680042115390062,"score_gpt":0.3802007256445857,"score_spread":0.333400304490685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}