{"id":"W2017049923","doi":"10.1161/circulationaha.111.030338","title":"Lack of Tissue Inhibitor of Metalloproteinases 2 Leads to Exacerbated Left Ventricular Dysfunction and Adverse Extracellular Matrix Remodeling in Response to Biomechanical Stress","year":2011,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Alberta; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; Heart and Stroke Foundation of Canada","keywords":"Matrix metalloproteinase; Pressure overload; Fibrosis; Extracellular matrix; Ventricular remodeling; TIMP1; Medicine; Type I collagen; Fibronectin; Tissue inhibitor of metalloproteinase; Muscle hypertrophy; Cell biology; Cardiac fibrosis; Internal medicine; Endocrinology; Biology; Heart failure; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005909707,0.0001142663,0.0003457985,0.0004040267,0.00002235062,0.000003704717,0.00003108438,0.0001291394,0.00002834607],"category_scores_gemma":[0.000214383,0.0001095074,0.00007817107,0.0003699558,0.00001898508,0.00008182036,0.00003673822,0.00007555242,0.000004990549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007230713,"about_ca_system_score_gemma":0.00003784159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001247596,"about_ca_topic_score_gemma":0.000006426101,"domain_scores_codex":[0.9987784,0.00009206904,0.0004747078,0.0002629386,0.0002513981,0.0001404923],"domain_scores_gemma":[0.9993592,0.00003068694,0.0001085189,0.0002216444,0.0001718366,0.0001081412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001454364,0.00009591537,0.01218858,0.0001641955,0.00001722856,0.00001112328,0.0005415296,0.007894969,0.9763988,0.00003862813,0.000002860575,0.001191787],"study_design_scores_gemma":[0.001516331,0.000426686,0.1918767,0.0008541944,0.0001743553,0.00003616257,0.0003506364,0.02386725,0.7805598,0.00006694612,0.00007253835,0.0001984566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979134,0.0006766252,0.01924611,0.00005916643,0.00009156241,0.0007515586,0.000007218291,0.00002000367,0.00001378075],"genre_scores_gemma":[0.9958877,0.000009871002,0.003971402,0.0000083125,0.00003929553,0.000006262033,0.00002007706,0.00001912071,0.00003798486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1958391,"threshold_uncertainty_score":0.4465582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04073435751558818,"score_gpt":0.292560044778598,"score_spread":0.2518256872630099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}