{"id":"W2017054061","doi":"10.1021/bi900631u","title":"Characterization of an RNA-Cleaving Deoxyribozyme with Optimal Activity at pH 5","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Deoxyribozyme; Cleave; Ribonucleotide; RNA; Nucleotide; Chemistry; DNA; Cleavage (geology); Enzyme; Biochemistry; Stereochemistry; Oligonucleotide; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003970471,0.0002956999,0.0002597346,0.0001579671,0.00008980154,0.0003523654,0.0002555214,0.0003070494,0.0003996805],"category_scores_gemma":[0.0004035875,0.0001210588,0.0001853929,0.000175282,0.0001744053,0.0001783735,0.0001138173,0.0003643969,0.0002978556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002139561,"about_ca_system_score_gemma":0.0001673388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002264763,"about_ca_topic_score_gemma":0.0003016559,"domain_scores_codex":[0.9997521,0.00004987319,0.00002803412,0.00005129984,0.00008327151,0.00003546053],"domain_scores_gemma":[0.9997998,0.00005676783,0.00005173119,0.00001421164,0.00003356487,0.00004394701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001262222,0.000005149137,0.00009309938,0.00001002661,0.000001152215,0.00001614061,0.000004801198,0.00008227367,0.9993004,0.00002640483,0.000003207442,0.0004446718],"study_design_scores_gemma":[0.000003254726,0.00008608742,0.0008662847,0.000001366292,0.000003335292,0.00009036971,0.000004956257,0.0008992914,0.9975961,0.0000136969,0.0004329476,0.000002359203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790221,0.000943553,0.01866617,0.00005255646,0.00001078309,0.00004696386,0.0002530124,0.0000531411,0.0009518103],"genre_scores_gemma":[0.9830204,0.0003675655,0.0152036,0.0000305764,0.000004022126,0.00002068488,0.0006546928,0.00002456348,0.0006739486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003996805,"threshold_uncertainty_score":0.002099752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005413584529067616,"score_gpt":0.2429778214413966,"score_spread":0.237564236912329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}