{"id":"W2017055835","doi":"10.1074/jbc.m212474200","title":"Adenine Release Is Fast in MutY-catalyzed Hydrolysis of G:A and 8-Oxo-G:A DNA Mismatches","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"DNA; Chemistry; AP site; Biochemistry; DNA glycosylase; DNA repair; Biophysics; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008813114,0.0008133755,0.0007779188,0.0004741783,0.0002083107,0.0006679466,0.0004945566,0.0008209387,0.0009248745],"category_scores_gemma":[0.001074611,0.0006903125,0.0004992637,0.0003085574,0.0003835213,0.0007941751,0.0006670248,0.001184592,0.0005912475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003702101,"about_ca_system_score_gemma":0.0002612244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007645634,"about_ca_topic_score_gemma":0.0006269308,"domain_scores_codex":[0.9987644,0.0001825938,0.00008607012,0.0003360737,0.0004555644,0.0001752998],"domain_scores_gemma":[0.998962,0.0003003264,0.0003147064,0.0001241446,0.0001712577,0.0001274773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003055421,0.00004469505,0.001345257,0.00009608508,0.00002960189,0.00008614473,0.00007114343,0.0001500856,0.9946843,0.0001172778,0.00002918985,0.003040707],"study_design_scores_gemma":[0.000008363786,0.0002266664,0.005231165,0.000006313751,0.000010662,0.0002233043,0.00002656615,0.001101342,0.9924977,0.00004110755,0.0006108565,0.00001592964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835684,0.002759069,0.01181489,0.00007117932,0.00003989262,0.00007273829,0.0003302655,0.0001722207,0.001171322],"genre_scores_gemma":[0.9859767,0.001034013,0.008671663,0.00005698769,0.00001352281,0.00007587378,0.0008367336,0.00007000948,0.003264542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009248745,"threshold_uncertainty_score":0.004660904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116385744650671,"score_gpt":0.2310223785355324,"score_spread":0.2193838040704653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}