{"id":"W2017068027","doi":"10.1016/j.yjmcc.2007.07.055","title":"Matrix metalloproteinase-2 degrades the cytoskeletal protein α-actinin in peroxynitrite mediated myocardial injury","year":2007,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Peroxynitrite; Desmin; Spectrin; Sarcomere; Cytoskeleton; Chemistry; Cell biology; Matrix metalloproteinase; Myocyte; Biochemistry; Internal medicine; Biology; Medicine; Vimentin; Enzyme; Superoxide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0021394,0.0002436762,0.0004549702,0.0001395796,0.0000707678,0.00002531699,0.0003185779,0.0002939193,0.000005186904],"category_scores_gemma":[0.0005396293,0.0001835472,0.0004188652,0.0001827787,0.0002502004,0.000008204056,0.0001302757,0.0004353861,0.000002722303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002770532,"about_ca_system_score_gemma":0.0001484015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001306622,"about_ca_topic_score_gemma":0.00000750268,"domain_scores_codex":[0.9979265,0.0005081903,0.0005961155,0.0002834895,0.000288226,0.0003974166],"domain_scores_gemma":[0.9990119,0.00005235177,0.0002927758,0.0003197836,0.0001521851,0.0001710059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005997422,0.00003449449,0.002659126,0.0000168708,0.0002748584,0.0009759085,0.00003315797,0.00007629837,0.9942495,0.00007946739,0.00008520837,0.0009154046],"study_design_scores_gemma":[0.001356234,0.0007044409,0.001782789,0.00002774179,0.0001305295,0.000604391,0.0002642262,0.000007140783,0.9876406,0.0002374976,0.00697988,0.000264494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815392,0.009977338,0.007550884,0.0002225685,0.0001852961,0.0003210008,0.00001166732,0.000006114538,0.0001858896],"genre_scores_gemma":[0.9985943,0.00009605194,0.0005606862,0.000217008,0.0004359708,0.0000128849,0.00002394312,0.00003406989,0.00002501986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01705512,"threshold_uncertainty_score":0.7484838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007224660516874907,"score_gpt":0.2457116775713944,"score_spread":0.2384870170545195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}