{"id":"W2017082020","doi":"10.1016/j.vaccine.2006.08.001","title":"Phase 1 first-in-human studies of the reactogenicity and immunogenicity of a recombinant meningococcal NspA vaccine in healthy adults","year":2006,"lang":"en","type":"article","venue":"Vaccine","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"GlaxoSmithKline (Canada); Dalhousie University; Izaak Walton Killam Health Centre","funders":"Clinical Trial Center, China Medical University Hospital","keywords":"Reactogenicity; Immunogenicity; Neisseria meningitidis; Medicine; Meningococcal vaccine; Immunoassay; Antibody; Adverse effect; Immunization; Immunology; Microbiology; Pharmacology; Biology; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003510664,0.0001755099,0.0005844379,0.0001696745,0.0001223808,0.000002926665,0.0001430782,0.0001454414,0.00007847813],"category_scores_gemma":[0.00008628309,0.000120854,0.0000862307,0.000348913,0.00002928843,0.00006583882,0.0001473103,0.0002234844,0.000001701375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004964088,"about_ca_system_score_gemma":0.00002434402,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01092455,"about_ca_topic_score_gemma":0.01536778,"domain_scores_codex":[0.9985332,0.0001604625,0.000785081,0.000247186,0.0000171595,0.0002569382],"domain_scores_gemma":[0.9991319,0.0001419053,0.0003175164,0.0003020698,0.00009600363,0.00001060239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004650534,0.00216664,0.2794003,0.0001583419,0.000125404,0.000001261357,0.0005328456,0.00000702396,0.710938,0.0004466195,0.0005268803,0.001046054],"study_design_scores_gemma":[0.03078982,0.002489075,0.8003931,0.0003477342,0.00006061964,0.00004913134,0.0002561169,0.000009159642,0.1621383,0.0004517918,0.002804988,0.0002101201],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935741,0.00493085,0.000001252586,0.0005595059,0.0004766242,0.0003965052,0.00002007271,0.00001412667,0.00002692499],"genre_scores_gemma":[0.9992807,0.0005437417,0.000012631,0.00001353748,0.00002453299,0.00001738794,0.00002120046,0.00001051159,0.00007575692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5487997,"threshold_uncertainty_score":0.9956618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01793300632863167,"score_gpt":0.2930305166503802,"score_spread":0.2750975103217486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}