{"id":"W2017098775","doi":"10.1021/mp0700357","title":"Use of Sandwich-Cultured Hepatocytes To Evaluate Impaired Bile Acid Transport as a Mechanism of Drug-Induced Hepatotoxicity","year":2007,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; National Cancer Institute","keywords":"Troglitazone; Hepatocyte; Transporter; Pharmacology; Bile acid; Drug; Chemistry; In vitro; Taurocholic acid; Peroxisome proliferator-activated receptor; Biochemistry; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000901238,0.0004073631,0.0008218951,0.0002868602,0.00006733118,0.000008570738,0.0002296763,0.0002142902,0.0001353923],"category_scores_gemma":[0.00005847275,0.0003549177,0.0004745705,0.0006622288,0.00008139179,0.00008862295,0.00003268325,0.0003128706,0.00001568342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009648369,"about_ca_system_score_gemma":0.0002326117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001112577,"about_ca_topic_score_gemma":0.00006410759,"domain_scores_codex":[0.9969008,0.00007485722,0.0008995513,0.0004743691,0.001040708,0.0006097291],"domain_scores_gemma":[0.9980973,0.00003800208,0.0002471555,0.0005627978,0.0004938204,0.0005609475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001465525,0.0005474594,0.001773351,0.0003605219,0.0003236768,0.0005991196,0.001316596,0.00002807152,0.9916109,0.0007036971,0.00001999972,0.001251018],"study_design_scores_gemma":[0.002785187,0.0003853139,0.001338606,0.0002394429,0.0008298922,0.00004188961,0.000205471,0.0004238011,0.9921522,0.0002449742,0.001007093,0.0003461318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9809433,0.0003012954,0.01613033,0.0002295774,0.000281259,0.001612482,0.00007172548,0.0001054361,0.000324641],"genre_scores_gemma":[0.9898261,0.00009025264,0.008661233,0.0009617071,0.00004137902,0.00002932267,0.0000634242,0.00007996977,0.0002466534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008882806,"threshold_uncertainty_score":0.9998903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04919185827435011,"score_gpt":0.3382993674279574,"score_spread":0.2891075091536072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}