{"id":"W2017109689","doi":"10.1517/17425255.2011.585968","title":"Have physiologically-based pharmacokinetic models delivered?","year":2011,"lang":"en","type":"article","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Heartland Health Research Alliance; U.S. Environmental Protection Agency","keywords":"Physiologically based pharmacokinetic modelling; In silico; Pharmacokinetics; Drug development; Drug; Human health; Computational biology; Computer science; Biochemical engineering; Pharmacology; Risk analysis (engineering); Medicine; Biology; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01928144,0.001226105,0.00250802,0.000912349,0.0008026046,0.007044174,0.002136166,0.006912608,0.006120347],"category_scores_gemma":[0.050723,0.001089457,0.001666249,0.001063673,0.003829572,0.01473554,0.002345154,0.01019524,0.006052902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005970111,"about_ca_system_score_gemma":0.006159112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006392593,"about_ca_topic_score_gemma":0.002590595,"domain_scores_codex":[0.9902595,0.004609035,0.000689243,0.001392168,0.00266718,0.0003828609],"domain_scores_gemma":[0.982557,0.007789297,0.001857353,0.002206211,0.005024846,0.0005652871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000687569,0.000428211,0.009239489,0.003142277,0.000437482,0.0006276995,0.00213934,0.03598046,0.008456554,0.4496728,0.052619,0.4365692],"study_design_scores_gemma":[0.0001606795,0.0009503081,0.00310625,0.001782654,0.0002968502,0.001197638,0.002077406,0.04493685,0.008909954,0.5402986,0.3959104,0.0003724254],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.02378687,0.09119985,0.2969258,0.5470275,0.01111488,0.0002866186,0.001069052,0.0009114803,0.02767802],"genre_scores_gemma":[0.4760123,0.1526418,0.1972745,0.1410757,0.00850197,0.0007507479,0.001525713,0.0007448153,0.02147256],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01928144,"threshold_uncertainty_score":0.1019711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2037785665111753,"score_gpt":0.4199347654763287,"score_spread":0.2161561989651535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}