{"id":"W2017125316","doi":"10.1093/toxsci/kfu244","title":"Cyclooxygenase-1 Serves a Vital Hepato-Protective Function in Chemically Induced Acute Liver Injury","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Liver injury; Cyclooxygenase; Oxidative stress; Inflammation; Prostaglandin; Pharmacology; Endocrinology; Arachidonic acid; Arachidonate 5-lipoxygenase; Chemistry; Prostaglandin E2; Apoptosis; Internal medicine; Medicine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446359,0.0004212987,0.0003342225,0.0002270321,0.0001544209,0.0002395185,0.0001261412,0.0002280216,0.00160438],"category_scores_gemma":[0.00009442885,0.00008113543,0.0002284305,0.0001703267,0.0001762265,0.0001960749,0.0002128433,0.0004664006,0.0002493081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897753,"about_ca_system_score_gemma":0.0002386928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001839311,"about_ca_topic_score_gemma":0.0002793486,"domain_scores_codex":[0.9999331,0.00001353471,0.000005062107,0.00001021583,0.00001375907,0.00002443004],"domain_scores_gemma":[0.9999259,0.000005410101,0.0000269707,0.000005730588,0.00001203473,0.0000240768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001650195,0.0002808799,0.005618444,0.001095718,0.00005239793,0.0007386447,0.00006322392,0.0001642619,0.9565622,0.001060223,0.001063427,0.03165033],"study_design_scores_gemma":[0.0001905756,0.004215126,0.09684837,0.000167594,0.0002967698,0.004472949,0.0002720189,0.001073966,0.8514921,0.001432676,0.03950384,0.00003407938],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8200611,0.1646422,0.006610177,0.001143197,0.0005113991,0.0001395249,0.0008324545,0.0001876238,0.005872287],"genre_scores_gemma":[0.9612191,0.03268341,0.001327422,0.0001602277,0.0001631465,0.00004663069,0.0005113356,0.000006657302,0.003882083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00160438,"threshold_uncertainty_score":0.00536716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02217983577336117,"score_gpt":0.2801729372673034,"score_spread":0.2579931014939422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}