{"id":"W2017140634","doi":"10.1016/j.bioelechem.2011.08.007","title":"Modulation of fibril formation by a beta-sheet breaker peptide ligand: An electrochemical approach","year":2011,"lang":"en","type":"article","venue":"Bioelectrochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"","keywords":"Thioflavin; Beta sheet; Electrochemistry; Fibril; Peptide; Chemistry; Biophysics; Amyloid beta; In vitro; Fluorescence; Combinatorial chemistry; Electrode; Biochemistry; Alzheimer's disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004777714,0.0002904775,0.0003205595,0.0001235374,0.0001971531,0.0005205341,0.0005673846,0.0007162815,0.0007391724],"category_scores_gemma":[0.0003950256,0.0002148621,0.000163341,0.0001159078,0.0002528852,0.0003738393,0.0002033246,0.0009972431,0.0001549422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002918207,"about_ca_system_score_gemma":0.0001104827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002313178,"about_ca_topic_score_gemma":0.0003902123,"domain_scores_codex":[0.9998488,0.00004119879,0.00001049976,0.00003499194,0.00003645606,0.00002792513],"domain_scores_gemma":[0.9998719,0.00005260509,0.00001817629,0.00001247939,0.00002779216,0.00001712443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008898458,0.00003812316,0.00003207819,0.00004934012,0.000005947665,0.00003288137,0.00002654435,0.00003887489,0.9970955,0.0002415295,0.00005582955,0.002294357],"study_design_scores_gemma":[0.00002289146,0.000172887,0.0001574923,0.000003772737,0.000009163788,0.00006220824,0.00001623655,0.0009167109,0.9977683,0.00006460871,0.0008004468,0.000005353137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9480607,0.004927915,0.04075726,0.001247157,0.0003467901,0.0001150025,0.0001286451,0.0002003592,0.004216161],"genre_scores_gemma":[0.983232,0.001764966,0.01206968,0.0004894936,0.00005937,0.00004867499,0.00006484996,0.00002042816,0.002250484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007391724,"threshold_uncertainty_score":0.00252676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02753103835998559,"score_gpt":0.2701960664204568,"score_spread":0.2426650280604712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}