{"id":"W2017153914","doi":"10.1371/journal.pone.0043903","title":"Glycoform and Net Charge Heterogeneity in gp120 Immunogens Used in HIV Vaccine Trials","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; York University; National Institutes of Health; International AIDS Vaccine Initiative","keywords":"Chinese hamster ovary cell; Biology; Neutralization; Monoclonal antibody; Virology; Baby hamster kidney cell; Hamster; HIV vaccine; Glycosylation; Antibody; Cell culture; Virus; Vaccination; Vaccine trial; Molecular biology; Immunology; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00145222,0.0001853314,0.0001730108,0.0002656304,0.0001269163,0.0003477305,0.0001415872,0.0002774709,0.0004914976],"category_scores_gemma":[0.001438453,0.00006821458,0.0001570755,0.0002460329,0.0002632933,0.0002034002,0.0002140363,0.0003450564,0.00009051391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002407271,"about_ca_system_score_gemma":0.00008882315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001291653,"about_ca_topic_score_gemma":0.0001165926,"domain_scores_codex":[0.99927,0.0003662519,0.00007888623,0.00007765092,0.0001491059,0.00005805555],"domain_scores_gemma":[0.9995009,0.0001535301,0.0001957448,0.00003016612,0.00006775755,0.00005191393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009757596,0.0003260238,0.2397629,0.0002516826,0.0003493801,0.000532284,0.0002941847,0.001230291,0.7056149,0.0002364714,0.000273815,0.04137034],"study_design_scores_gemma":[0.0003843979,0.01422926,0.713315,0.00005363447,0.0003345748,0.004345146,0.0002516565,0.002837718,0.2604741,0.0004979576,0.003245291,0.00003130181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983667,0.0006570898,0.0004928103,0.00002593026,0.000005826455,0.00003032217,0.00006615232,0.000003846229,0.0003513596],"genre_scores_gemma":[0.9992263,0.0001047376,0.0004317661,0.00003529357,0.000005329264,0.000017954,0.0001217794,0.000002289665,0.00005439993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00145222,"threshold_uncertainty_score":0.007680178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09622163284356552,"score_gpt":0.2981595150360374,"score_spread":0.2019378821924719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}