{"id":"W2017171169","doi":"10.1371/journal.pone.0022510","title":"Shikonin Increases Glucose Uptake in Skeletal Muscle Cells and Improves Plasma Glucose Levels in Diabetic Goto-Kakizaki Rats","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stockholms Universitet; Hospital for Sick Children; Medical Research Council; Vetenskapsrådet; National Health and Medical Research Council; Karolinska Institutet","keywords":"Glucose uptake; GLUT4; Internal medicine; Skeletal muscle; Endocrinology; Insulin; Glucose transporter; Glucose homeostasis; Myocyte; Carbohydrate metabolism; Chemistry; Snf3; Insulin resistance; Biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004885849,0.0003232181,0.0004864794,0.0002316508,0.0001213976,0.00003030921,0.0002713071,0.0002980863,0.0007659025],"category_scores_gemma":[0.00008466769,0.0003268449,0.00006411001,0.0002849502,0.0002984461,0.0002410191,0.0001948413,0.0007271112,0.0001103451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007585157,"about_ca_system_score_gemma":0.00006771169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002243702,"about_ca_topic_score_gemma":0.0003608672,"domain_scores_codex":[0.9978378,0.000374799,0.0004621487,0.0005075115,0.0001782869,0.0006394886],"domain_scores_gemma":[0.9990908,0.0002534688,0.0001349392,0.0002095352,0.00005170884,0.0002595629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001988258,0.007640966,0.06525492,0.0001730649,0.0001810502,0.0002394395,0.001039021,0.000001696257,0.9141326,0.00016425,0.0000605555,0.01091362],"study_design_scores_gemma":[0.002440604,0.0002525092,0.3863396,0.0001093517,0.0001201763,0.000003066826,0.0001593928,0.00140636,0.6079835,0.0002715342,0.0005505322,0.0003633748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963129,0.001097802,0.000001874115,0.00007653391,0.0001859065,0.0006171727,0.0001299753,0.00005729847,0.001520574],"genre_scores_gemma":[0.9978034,0.0007113384,0.0005595951,0.0004570016,0.00009593964,0.00008999507,0.00001529784,0.0000378291,0.0002296291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3210846,"threshold_uncertainty_score":0.9999183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1643071748128553,"score_gpt":0.3333436180146576,"score_spread":0.1690364432018023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}