{"id":"W2017181626","doi":"10.3389/fonc.2014.00084","title":"Targeting PI3K/mTOR Signaling in Cancer","year":2014,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1030,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"UniBern Forschungsstiftung; European Commission; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; mTORC2; Signal transduction; RPTOR; Phosphatidylinositol; Cancer research; Biology; mTORC1; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094187,0.0003045755,0.0002826432,0.0006421118,0.0002581833,0.000574998,0.0002408159,0.0004111841,0.0008971381],"category_scores_gemma":[0.00008437857,0.000112982,0.0001601219,0.0005909447,0.000312883,0.0004547535,0.0003883272,0.0007307092,0.0005343912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007588189,"about_ca_system_score_gemma":0.000608518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004132196,"about_ca_topic_score_gemma":0.001024228,"domain_scores_codex":[0.9999352,0.00001208491,0.000004970821,0.000009017722,0.00002008785,0.0000185376],"domain_scores_gemma":[0.9999794,0.00000334079,0.000004016177,0.000001491183,0.000005357781,0.000006314971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000738361,0.000384988,0.0009720283,0.002578006,0.00004713572,0.0008952929,0.0001779107,0.003076631,0.301001,0.04175797,0.0214176,0.6269531],"study_design_scores_gemma":[0.0001748565,0.001166338,0.005398254,0.000505582,0.0001462096,0.004688985,0.0001752104,0.004369251,0.2406346,0.02656196,0.7161098,0.00006886903],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.06563937,0.890205,0.01047916,0.008163457,0.0009834457,0.00006668355,0.0002419052,0.0003832561,0.02383777],"genre_scores_gemma":[0.2768284,0.7044299,0.008408602,0.0013749,0.0007476426,0.00005657748,0.0002108099,0.00002979576,0.007913409],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008971381,"threshold_uncertainty_score":0.005505562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.010323086417355,"score_gpt":0.2898932553222411,"score_spread":0.2795701689048861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}