{"id":"W2017181626","doi":"10.3389/fonc.2014.00084","title":"Targeting PI3K/mTOR Signaling in Cancer","year":2014,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1030,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"UniBern Forschungsstiftung; European Commission; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; mTORC2; Signal transduction; RPTOR; Phosphatidylinositol; Cancer research; Biology; mTORC1; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007075915,0.0001907352,0.000346976,0.000154135,0.00004437545,0.00001124515,0.0004024956,0.0003836647,0.00006322625],"category_scores_gemma":[0.0003922395,0.0002074112,0.00006352382,0.0001900477,0.0001153186,0.000005549825,0.0001431159,0.0002771773,0.000006486378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003161374,"about_ca_system_score_gemma":0.0002413902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001674811,"about_ca_topic_score_gemma":0.0002375213,"domain_scores_codex":[0.9982322,0.0002519546,0.0003847425,0.0005072081,0.0001175119,0.0005063716],"domain_scores_gemma":[0.9994106,0.00004269428,0.0001359564,0.0002827071,0.00005060107,0.00007744071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003516345,0.0001685004,0.2401441,0.00004904261,0.00005332319,0.00002561247,0.0003113338,0.01785468,0.6085228,0.00004650649,0.100447,0.03202542],"study_design_scores_gemma":[0.003972506,0.00122984,0.00414439,0.000105859,0.00003288263,0.00001026802,0.0004813313,0.008418744,0.1327205,0.001277997,0.8467042,0.0009015193],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96739,0.007131127,0.01626576,0.0008137395,0.00453929,0.0003197059,0.00001268763,0.00002836867,0.003499288],"genre_scores_gemma":[0.9814138,0.0002446939,0.01575897,0.001063097,0.0009269617,0.0001408073,0.00003854038,0.00004215894,0.0003709766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7462571,"threshold_uncertainty_score":0.8457982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.010323086417355,"score_gpt":0.2898932553222411,"score_spread":0.2795701689048861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}