{"id":"W2017189238","doi":"10.1023/b:appt.0000045791.55282.91","title":"Activation of multidomain and BH3-only pro-apoptotic Bcl-2 family members in p53-defective cells","year":2004,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal; Hôpital Notre-Dame","funders":"National Cancer Institute","keywords":"Apoptosis; Camptothecin; Bcl-2 family; Immunoprecipitation; VDAC1; Bcl-2-associated X protein; Cell biology; Molecular biology; DNA damage; Topoisomerase; Biology; Mitochondrion; Chemistry; Programmed cell death; Cell culture; DNA; Biochemistry; Caspase 3; Genetics; Bacterial outer membrane; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247862,0.0001205158,0.0001360361,0.00007152215,0.000036039,0.00000852611,0.00005436437,0.0001482372,0.000004022394],"category_scores_gemma":[0.00002312517,0.0001135636,0.0000512991,0.0001149161,0.00004893131,0.000007646654,0.00004343515,0.00005479895,0.000001520889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003005025,"about_ca_system_score_gemma":0.00004440061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002584941,"about_ca_topic_score_gemma":0.00003824592,"domain_scores_codex":[0.9992715,0.00003333407,0.0001829308,0.0002639453,0.000100552,0.0001477108],"domain_scores_gemma":[0.9996591,0.0000119222,0.00008867357,0.0001542541,0.00004579223,0.00004023248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005339611,0.00008148167,0.0005087831,0.00002930342,0.00002165516,2.065778e-7,0.0001876198,0.001002187,0.9941456,0.0003181127,0.00001638601,0.00363531],"study_design_scores_gemma":[0.00106181,0.0002017314,0.01100162,0.00003993276,0.0000151827,0.000001491526,0.0002511905,0.00007883475,0.9864985,0.0004503632,0.0002627619,0.0001366186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967423,0.0001099184,0.002322827,0.00005614188,0.0000672077,0.0003061748,0.000004821065,0.00000696197,0.0003836227],"genre_scores_gemma":[0.9973664,0.00022174,0.002160048,0.00005470544,0.00003687167,0.00001769157,0.00003466927,0.00001586604,0.00009199556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01049283,"threshold_uncertainty_score":0.463099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007262248643669666,"score_gpt":0.2232818597507421,"score_spread":0.2160196111070725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}