{"id":"W2017208620","doi":"10.1073/pnas.0911813107","title":"Structure of the <i>Plasmodium falciparum</i> M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Exopeptidase; Aminopeptidase; Plasmodium falciparum; Random hexamer; Active site; Biology; Biochemistry; Enzyme; Amino acid; Binding site; Cell biology; Leucine; Malaria; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037351,0.000395209,0.0004446444,0.0001317688,0.0002616587,0.000505552,0.0007009378,0.0004039345,0.001157361],"category_scores_gemma":[0.0001591336,0.0002002864,0.000243033,0.0002373597,0.0003651934,0.0002392298,0.0001691583,0.0009320487,0.0005445015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006106636,"about_ca_system_score_gemma":0.0005377752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002306183,"about_ca_topic_score_gemma":0.001064571,"domain_scores_codex":[0.999958,0.000009597713,0.00000236944,0.00000680781,0.00001557344,0.000007563018],"domain_scores_gemma":[0.9999315,0.000009213235,0.00002298927,0.000003442721,0.00001152806,0.00002130939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002355214,0.0002742573,0.007606332,0.001468621,0.0001261679,0.003918665,0.0004054505,0.03028767,0.906945,0.01316777,0.007044922,0.02639991],"study_design_scores_gemma":[0.001156615,0.003518112,0.04821527,0.0004916347,0.0003011266,0.009234183,0.001365392,0.1405209,0.631014,0.008074228,0.1558402,0.0002682984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699734,0.01320651,0.006505879,0.001213964,0.0001828667,0.0000661398,0.00109574,0.0001967493,0.007558807],"genre_scores_gemma":[0.9756495,0.007486743,0.008366646,0.0003800057,0.00007932411,0.00004964478,0.004095732,0.00005361393,0.003838824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002306183,"threshold_uncertainty_score":0.004585505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03267485871986641,"score_gpt":0.2957051802939436,"score_spread":0.2630303215740772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}