{"id":"W2017236738","doi":"10.1074/jbc.c100467200","title":"Determining the Dimensions of the Drug-binding Domain of Human P-glycoprotein Using Thiol Cross-linking Compounds as Molecular Rulers","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":175,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canadian Institutes of Health Research","funders":"National Cancer Institute","keywords":"Thiol; Glycoprotein; Drug; Chemistry; P-glycoprotein; Domain (mathematical analysis); Computational biology; Pharmacology; Biochemistry; Medicine; Biology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002163558,0.0002433068,0.0001374393,0.0001704037,0.0001248188,0.0002436088,0.0002047805,0.0002542085,0.0005603699],"category_scores_gemma":[0.0003966529,0.0002259291,0.0001616218,0.0001492915,0.000192327,0.0003112538,0.0001566539,0.0004115223,0.0002043475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539067,"about_ca_system_score_gemma":0.0001070338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002626377,"about_ca_topic_score_gemma":0.0003454188,"domain_scores_codex":[0.9998455,0.00003747904,0.00001715111,0.0000377506,0.00004962118,0.00001246726],"domain_scores_gemma":[0.9996787,0.000108622,0.0001121444,0.00002979868,0.00003112493,0.00003967673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003377347,0.000007987626,0.000301398,0.00001044252,0.000003840181,0.00001304333,0.0000150263,0.0001062838,0.9990779,0.000039401,0.000008814841,0.0003820623],"study_design_scores_gemma":[0.00000598826,0.0001535608,0.002203583,0.000001897305,0.000009504328,0.00008373838,0.00001695749,0.001144549,0.995702,0.00003099319,0.0006427437,0.000004473884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944602,0.0004707066,0.004423457,0.00004282217,0.000005586195,0.00002127712,0.0001356963,0.00003082645,0.0004094673],"genre_scores_gemma":[0.9837691,0.0004834206,0.01445228,0.00004007068,0.000006224766,0.00006087994,0.0005056254,0.00002436867,0.00065803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005603699,"threshold_uncertainty_score":0.001874626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02956435606157324,"score_gpt":0.3040866667589144,"score_spread":0.2745223106973412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}