{"id":"W2017308202","doi":"10.1073/pnas.1203210109","title":"Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; National Key Research and Development Program of China; Higher Education Discipline Innovation Project; Ministry of Education of the People's Republic of China; National Natural Science Foundation of China","keywords":"DNA replication factor CDT1; FOXO3; Cell biology; Cell cycle; Biology; Transcription factor; Licensing factor; DNA replication; DNA re-replication; Pre-replication complex; Origin recognition complex; Control of chromosome duplication; Eukaryotic DNA replication; Genetics; DNA; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007134863,0.000191523,0.0001042815,0.0001645224,0.000222651,0.0002884472,0.0001123753,0.0001240167,0.001040391],"category_scores_gemma":[0.00009166743,0.0000874713,0.0001644499,0.0001107814,0.0002933248,0.0001703675,0.000229654,0.0002630178,0.0002173985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007279338,"about_ca_system_score_gemma":0.0003011996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0016314,"about_ca_topic_score_gemma":0.00372439,"domain_scores_codex":[0.999953,0.000004846561,0.000002565226,0.00001398159,0.000009917695,0.00001567237],"domain_scores_gemma":[0.999958,0.000004527378,0.00001441246,0.00000311177,0.000005585594,0.0000143322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001346009,0.00001183635,0.0006593677,0.00002527052,0.000002992505,0.00003823846,0.00001440203,0.00008858913,0.9963927,0.0002712792,0.0001150325,0.00224571],"study_design_scores_gemma":[0.00004322454,0.0000959637,0.01753254,0.000010701,0.00001180154,0.0001797906,0.00005620139,0.002572216,0.9724067,0.0004824396,0.006599856,0.000008469449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901341,0.003065657,0.003473154,0.0002764957,0.00004782754,0.00001185312,0.0003424007,0.0001322813,0.002516248],"genre_scores_gemma":[0.9957937,0.00082714,0.001278683,0.00004380917,0.000006552666,0.000007954068,0.0002125729,0.00001665227,0.001813081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0016314,"threshold_uncertainty_score":0.005281568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05284193547043101,"score_gpt":0.3308950053125251,"score_spread":0.278053069842094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}