{"id":"W2017310978","doi":"10.1089/hum.2010.171","title":"Rational Design of Murine Secreted Alkaline Phosphatase for Enhanced Performance as a Reporter Gene in Mouse Gene Therapy Preclinical Studies","year":2010,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; ALS Society of Canada","keywords":"Alkaline phosphatase; Genetic enhancement; Reporter gene; Gene; Rational design; Biology; Cancer research; Genetics; Gene expression; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001100367,0.0006232538,0.0004887198,0.0004239181,0.0001812077,0.0006579082,0.0005069741,0.0006403237,0.0006003724],"category_scores_gemma":[0.0005585225,0.0003807342,0.0006282817,0.0003343854,0.000399297,0.0004555356,0.0003494699,0.001046717,0.0004071803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000816856,"about_ca_system_score_gemma":0.0007812362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00059207,"about_ca_topic_score_gemma":0.0008910886,"domain_scores_codex":[0.999419,0.0001238612,0.0000603451,0.00008347096,0.0001973636,0.000115916],"domain_scores_gemma":[0.9996839,0.00005591035,0.00009916278,0.00002742795,0.00007846412,0.00005522599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001229889,0.0001049671,0.0001764269,0.00007589914,0.00001589128,0.0001002758,0.00003100269,0.002308782,0.9924657,0.001100352,0.00008353605,0.003414195],"study_design_scores_gemma":[0.0000539221,0.0007738292,0.0003582078,0.000007379052,0.00002649015,0.0001289879,0.00001396087,0.00328691,0.9906943,0.0001344303,0.004506448,0.0000151851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8403603,0.003483071,0.1483322,0.0008212535,0.0001367894,0.001054856,0.0004405958,0.0004225776,0.004948479],"genre_scores_gemma":[0.9018493,0.003677411,0.09074453,0.0002084691,0.00003139933,0.0003560612,0.0004815758,0.00007734004,0.002574011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100367,"threshold_uncertainty_score":0.005926728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0866882838483696,"score_gpt":0.3914373156831697,"score_spread":0.3047490318348001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}