{"id":"W2017310978","doi":"10.1089/hum.2010.171","title":"Rational Design of Murine Secreted Alkaline Phosphatase for Enhanced Performance as a Reporter Gene in Mouse Gene Therapy Preclinical Studies","year":2010,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital","funders":"Canadian Institutes of Health Research; ALS Society of Canada","keywords":"Alkaline phosphatase; Genetic enhancement; Reporter gene; Gene; Rational design; Biology; Cancer research; Genetics; Gene expression; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001491082,0.0003674623,0.0004964195,0.0001377273,0.000164996,0.00002313486,0.0004574172,0.0002572131,0.000237114],"category_scores_gemma":[0.0001128305,0.0003259452,0.0001868629,0.0001603512,0.0002896987,0.00001582997,0.00007797605,0.0002312999,0.000006842258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002526958,"about_ca_system_score_gemma":0.0002858535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001356023,"about_ca_topic_score_gemma":0.0001091113,"domain_scores_codex":[0.9973695,0.0002056501,0.0008448963,0.0007287185,0.0003596066,0.0004916683],"domain_scores_gemma":[0.9980428,0.00008676272,0.000326406,0.0009427594,0.0004799935,0.000121297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01383128,0.0004523367,0.0002319619,0.00001638183,0.0003654983,0.000006072993,0.0002222461,0.0004868206,0.9767466,0.000008271599,0.0002602178,0.007372279],"study_design_scores_gemma":[0.006588682,0.00828931,0.0003972297,0.000008869773,0.000008435813,0.00001627761,0.00001859456,0.0002166081,0.9826242,0.0001827674,0.001298794,0.0003502671],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912834,0.005184737,0.001554488,0.00008116756,0.00014104,0.001632812,0.00008410598,0.00002493926,0.00001333151],"genre_scores_gemma":[0.981073,0.01064387,0.004806495,0.0005223942,0.0005555713,0.0006879881,0.0008183094,0.0000911731,0.000801222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0102104,"threshold_uncertainty_score":0.9999192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0866882838483696,"score_gpt":0.3914373156831697,"score_spread":0.3047490318348001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}