{"id":"W2017320674","doi":"10.1111/j.1469-7793.2001.00681.x","title":"Contribution of potential EF hand motifs to the calcium‐dependent gating of a mouse brain large conductance, calcium‐sensitive K<sup>+</sup> channel","year":2001,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Alberta Heritage Foundation for Medical Research; Heart and Stroke Foundation of Canada","keywords":"Gating; Calcium; Chemistry; Depolarization; Voltage-dependent calcium channel; Biophysics; Calcium channel; Conductance; Binding site; T-type calcium channel; Membrane potential; Calcium-activated potassium channel; R-type calcium channel; Biochemistry; Biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007581717,0.0001219696,0.0002649844,0.00006010224,0.000130995,0.000005568686,0.0001740186,0.0001206117,0.00002584471],"category_scores_gemma":[0.0002676298,0.0000742425,0.0001394743,0.0001161476,0.0001434433,0.000008342967,0.00007988135,0.0001507893,0.00000315153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001939397,"about_ca_system_score_gemma":0.00005526258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000256951,"about_ca_topic_score_gemma":0.00001191613,"domain_scores_codex":[0.9986932,0.0003659942,0.0004289795,0.0001211704,0.000176642,0.0002140345],"domain_scores_gemma":[0.998522,0.00006273861,0.0004882585,0.0001918634,0.0006797516,0.00005534582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001087199,0.00007594671,0.00002069632,0.000006781147,0.0001004404,0.000001394488,0.0005387809,0.03927229,0.9575349,0.00008697798,0.001184928,0.00008966683],"study_design_scores_gemma":[0.001581222,0.0008829941,0.002009155,0.00002551884,0.00005396975,0.0001446955,0.001511795,0.007288462,0.9852602,0.0001639944,0.0009781865,0.00009973699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9586852,0.0001343696,0.03948158,0.001183083,0.0002703588,0.0001762776,0.00004228682,0.000001989739,0.00002481552],"genre_scores_gemma":[0.9984238,0.00004678828,0.00002397888,0.0004678747,0.0007229049,0.000002265716,0.00003636625,0.0000107104,0.0002653673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03973851,"threshold_uncertainty_score":0.3027522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01457955394247585,"score_gpt":0.2623886617498071,"score_spread":0.2478091078073313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}