{"id":"W2017394346","doi":"10.1016/s0009-2797(00)00246-5","title":"Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity","year":2001,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Alcohol dehydrogenase; Glutathione; Cytotoxicity; Biochemistry; Catalase; Pharmacology; Hepatocyte; Alcohol; Enzyme; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002828616,0.0004818355,0.000227439,0.0003538862,0.0002078143,0.000277518,0.0001654995,0.0003047402,0.004070447],"category_scores_gemma":[0.0003132563,0.000212915,0.0003502524,0.0002831427,0.0002182762,0.0002606202,0.0002647583,0.0004697424,0.0008807707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004503703,"about_ca_system_score_gemma":0.0003475412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009309203,"about_ca_topic_score_gemma":0.00113537,"domain_scores_codex":[0.9997649,0.00008453441,0.00001408047,0.00002243678,0.00004549495,0.00006863219],"domain_scores_gemma":[0.9998239,0.00005460419,0.00003322408,0.00003072022,0.00003291391,0.00002468613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002416559,0.0002348577,0.001384917,0.00008524951,0.0000368418,0.0006022415,0.00003842332,0.0002878085,0.9901103,0.0003614975,0.0002181276,0.0042232],"study_design_scores_gemma":[0.0000314653,0.0005591799,0.001943341,0.000002240849,0.0000151505,0.0002599026,0.00002031537,0.0003577062,0.9960194,0.00005185258,0.0007360814,0.000003203495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924252,0.0007556004,0.003723114,0.0001893331,0.00006564736,0.00005752772,0.0003030536,0.00009692783,0.00238354],"genre_scores_gemma":[0.9965926,0.0003764003,0.0005366528,0.00003349985,0.00001308754,0.00002410613,0.0003593098,0.00001125328,0.002053038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004070447,"threshold_uncertainty_score":0.01361704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2703021651535082,"score_gpt":0.4700398916383994,"score_spread":0.1997377264848912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}