{"id":"W2017409119","doi":"10.1016/j.ymeth.2004.08.020","title":"Biomarker discovery in biological fluids","year":2005,"lang":"en","type":"article","venue":"Methods","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":false,"ca_institutions":"Caprion (Canada)","funders":"","keywords":"Biomarker discovery; Biomarker; Computational biology; Drug discovery; Prioritization; Identification (biology); Drug development; Proteomics; Biology; Bioinformatics; Drug; Pharmacology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00200788,0.001027899,0.0007622659,0.001754769,0.0005077302,0.001316112,0.0007392745,0.00108461,0.0009164495],"category_scores_gemma":[0.002938074,0.0005022043,0.0004114679,0.0007754586,0.0008157911,0.001197022,0.001183264,0.00116459,0.001006461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005615021,"about_ca_system_score_gemma":0.0007576582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002751408,"about_ca_topic_score_gemma":0.0004289853,"domain_scores_codex":[0.9988163,0.0003747763,0.00006173695,0.0002355844,0.0004262296,0.00008530577],"domain_scores_gemma":[0.9992101,0.0003134799,0.0001201137,0.00008942879,0.0001885328,0.00007834068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002498,0.0001131953,0.002101827,0.0008464449,0.00008927668,0.0002260248,0.0001493036,0.0009716031,0.8894383,0.0108837,0.002713381,0.09221718],"study_design_scores_gemma":[0.00002949487,0.0001870844,0.001168464,0.00007317322,0.00005481373,0.0006150551,0.00005144905,0.008875256,0.9579828,0.009793346,0.02113182,0.00003718778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.1281158,0.03505684,0.8239045,0.003688114,0.0008767255,0.0003427262,0.0008103372,0.001479063,0.005725881],"genre_scores_gemma":[0.5319486,0.02807497,0.4180986,0.002303931,0.0006617517,0.0009552951,0.001227678,0.0002135546,0.01651556],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.00200788,"threshold_uncertainty_score":0.01061887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05483947805572032,"score_gpt":0.3941371904418794,"score_spread":0.3392977123861591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}