{"id":"W2017414584","doi":"10.1002/jps.22282","title":"Application of Extrinsic Fluorescence Spectroscopy for the High Throughput Formulation Screening of Aluminum-Adjuvanted Vaccines","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sanofi (Canada)","funders":"","keywords":"Antigenicity; Chemistry; Adsorption; Antigen; High-throughput screening; Fluorescence spectroscopy; Hydroxide; Chromatography; Fluorescence; Biochemistry; Organic chemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001112264,0.00005903821,0.000113394,0.00003013978,0.00009308834,0.00001103007,0.0003261726,0.0000478874,0.00001464321],"category_scores_gemma":[0.0003577058,0.00003612418,0.00008280315,0.0001578683,0.0002421043,0.00001741653,0.00003131152,0.00009990827,1.700695e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003826057,"about_ca_system_score_gemma":0.0000687622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008886771,"about_ca_topic_score_gemma":0.000006912364,"domain_scores_codex":[0.9991667,0.00003118416,0.0003537508,0.0001189594,0.0002194107,0.0001099569],"domain_scores_gemma":[0.9990612,0.0001045821,0.0003568729,0.0001289796,0.0003032397,0.00004513095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001392575,0.00005068731,0.00514582,0.00001467537,0.00001142659,3.289944e-8,0.00001823571,0.00005857144,0.9588245,0.002060422,0.00002077876,0.0336556],"study_design_scores_gemma":[0.0004283078,0.0002171052,0.02303881,0.000006883355,0.00002481805,0.000006308233,0.00004643933,0.009434893,0.9624309,0.0008230198,0.003498416,0.00004410254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7614332,0.000586911,0.2362339,0.001241616,0.0001678419,0.0002882983,0.0000075721,0.000001964724,0.00003870212],"genre_scores_gemma":[0.9780523,0.0001119583,0.02163189,0.00003822402,0.0001516358,0.00000557165,0.000001680602,0.000002557586,0.000004252177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2166191,"threshold_uncertainty_score":0.1473101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03247019914569498,"score_gpt":0.3667805328281384,"score_spread":0.3343103336824435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}