{"id":"W2017429464","doi":"10.1371/journal.pone.0107421","title":"Ethanol Impairs Intestinal Barrier Function in Humans through Mitogen Activated Protein Kinase Signaling: A Combined In Vivo and In Vitro Approach","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"MAPK/ERK pathway; Myosin light-chain kinase; Occludin; Protein kinase A; Cell biology; Intestinal permeability; Tight junction; Phosphorylation; Myosin; Kinase; Biology; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002749295,0.0006142954,0.0004909091,0.0002751471,0.0001504014,0.0002122746,0.0001817405,0.000382509,0.001824093],"category_scores_gemma":[0.0001468347,0.000217862,0.0003374857,0.0002115551,0.0002429749,0.0002598495,0.0001906846,0.0004909075,0.0003462419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312538,"about_ca_system_score_gemma":0.0001592969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004448854,"about_ca_topic_score_gemma":0.0008464298,"domain_scores_codex":[0.9998591,0.00005791322,0.000009598887,0.00002666935,0.00002571595,0.00002091477],"domain_scores_gemma":[0.9999264,0.0000167786,0.00002068086,0.00001346286,0.000007984832,0.0000146545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007017797,0.00130551,0.004771296,0.0005000609,0.0001338967,0.0003189457,0.00003629165,0.0002155949,0.9706688,0.00006305789,0.0002475564,0.01472128],"study_design_scores_gemma":[0.0008189176,0.06976294,0.1477184,0.0001284924,0.00110375,0.003024798,0.0002159525,0.00264017,0.7649559,0.0002853791,0.009298602,0.00004660623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726306,0.02012468,0.005092284,0.0002424672,0.00006999704,0.0001844317,0.0004588332,0.00007989599,0.001116905],"genre_scores_gemma":[0.9827632,0.01230834,0.002403453,0.0002178617,0.00006718025,0.0001389189,0.000568688,0.00001710518,0.001515374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824093,"threshold_uncertainty_score":0.006102145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05022752582043608,"score_gpt":0.234088130014497,"score_spread":0.1838606041940609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}