{"id":"W2017556424","doi":"10.1073/pnas.0708874105","title":"MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":251,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique","funders":"","keywords":"Ubiquitin ligase; Cell biology; MHC class II; Regulator; MHC class I; Internalization; Ubiquitin; Antigen presentation; Chemistry; Antigen processing; Receptor; Major histocompatibility complex; Immune system; Biology; T cell; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009343336,0.0001661639,0.000126676,0.00008737343,0.0001126633,0.0003324442,0.00008782007,0.00009968533,0.001010454],"category_scores_gemma":[0.0001747488,0.00008198661,0.0001343242,0.00009220142,0.0001163874,0.0001139559,0.0001341903,0.0002910713,0.0005252886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002708035,"about_ca_system_score_gemma":0.0001329556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002951771,"about_ca_topic_score_gemma":0.0001750063,"domain_scores_codex":[0.9999162,0.00001169073,0.000007267294,0.00001870127,0.00002009034,0.00002602712],"domain_scores_gemma":[0.9999111,0.00001164141,0.00003145909,0.00001365064,0.0000132943,0.00001885927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001010259,0.000005870814,0.0003765685,0.00001106013,0.000002349514,0.00005076429,0.000007679406,0.00002013278,0.9982865,0.00007295265,0.00003672368,0.001028305],"study_design_scores_gemma":[0.000008446924,0.00008009626,0.005824128,0.000002022071,0.00000798987,0.0004136711,0.00001775163,0.0002643342,0.9910143,0.00005404312,0.002310806,0.000002230498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955204,0.001515832,0.001786543,0.00008258018,0.00001655729,0.000008767376,0.0001515959,0.00004332303,0.0008743847],"genre_scores_gemma":[0.9969432,0.0005818953,0.0008047719,0.00003201944,0.00001215983,0.000007040329,0.0002690376,0.00001150175,0.00133844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010454,"threshold_uncertainty_score":0.003380299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03444267303219701,"score_gpt":0.2871153803803614,"score_spread":0.2526727073481644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}