{"id":"W2017568512","doi":"10.1021/ac202787n","title":"Functional Screening of Cytochrome P450 Activity and Uncoupling by Capillary Electrophoresis","year":2011,"lang":"en","type":"letter","venue":"Analytical Chemistry","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Chemistry; Cytochrome P450; Xenobiotic; Substrate (aquarium); Biochemistry; Monooxygenase; Cytochrome; Capillary electrophoresis; Metabolism; Enzyme; Chromatography; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007192231,0.0006432468,0.0003711098,0.0003745497,0.000205225,0.00032641,0.0005453666,0.001064346,0.0008342298],"category_scores_gemma":[0.001716148,0.0001729806,0.0001797517,0.0003546113,0.0003289435,0.0002407576,0.0002011704,0.000678324,0.0006554058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004756151,"about_ca_system_score_gemma":0.0001959101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006481073,"about_ca_topic_score_gemma":0.0008785488,"domain_scores_codex":[0.9989925,0.0002563557,0.00005506142,0.0001460381,0.000456146,0.00009400976],"domain_scores_gemma":[0.9988991,0.0005402142,0.0001346414,0.0001037651,0.0002832834,0.00003898419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007933742,0.00003767638,0.0007063722,0.00007808105,0.00000806515,0.0001858306,0.00003020081,0.00007217943,0.9873591,0.0002936475,0.0004476921,0.01070165],"study_design_scores_gemma":[0.00001409235,0.0003824415,0.004295386,0.000008021131,0.00001641772,0.0008979101,0.00001887118,0.001851647,0.9870459,0.0001835482,0.005274022,0.00001170072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.896603,0.01245775,0.07386108,0.003497072,0.0003587489,0.0003696743,0.0008554208,0.0007240316,0.01127317],"genre_scores_gemma":[0.9235884,0.006312381,0.05942355,0.001206197,0.0001341169,0.0004871851,0.001747556,0.00009415125,0.007006533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001064346,"threshold_uncertainty_score":0.00380367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09038373432684911,"score_gpt":0.3632725842239597,"score_spread":0.2728888498971106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}