{"id":"W2017587618","doi":"10.1016/j.pnpbp.2004.12.008","title":"Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging","year":2005,"lang":"en","type":"review","venue":"Progress in Neuro-Psychopharmacology and Biological Psychiatry","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"","keywords":"Cholinergic; Dementia; Memory impairment; Cognition; Neuroscience; Acetylcholinesterase; Neuropathology; Cognitive decline; Psychology; Acetylcholinesterase inhibitor; Working memory; Donepezil; Effects of sleep deprivation on cognitive performance; Medicine; Disease; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012996,0.0009621694,0.001655399,0.00231096,0.0002924094,0.0009617864,0.0009647131,0.001705514,0.002561741],"category_scores_gemma":[0.0006464503,0.0002340229,0.000514175,0.001685715,0.0009531271,0.001877682,0.0006597979,0.002933207,0.001300776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006922688,"about_ca_system_score_gemma":0.001132723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001622241,"about_ca_topic_score_gemma":0.002418589,"domain_scores_codex":[0.9998857,0.00001650423,0.00002000858,0.00002833198,0.00003909302,0.00001038051],"domain_scores_gemma":[0.9995579,0.0002398098,0.0000390466,0.0000202574,0.0001091639,0.00003379762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002219253,0.0001215014,0.0003961835,0.01105443,0.0001561699,0.001829797,0.0001002555,0.0004361581,0.009568518,0.01476414,0.03015958,0.9311912],"study_design_scores_gemma":[0.00004895874,0.0001643185,0.001929458,0.002199841,0.0002081811,0.005179771,0.00009971156,0.0001142575,0.002201276,0.009285892,0.9785277,0.00004050818],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000268483,0.9972591,0.0003631992,0.0004955363,0.0002900229,0.000003215175,0.00001701082,0.00000621646,0.001297129],"genre_scores_gemma":[0.001709182,0.9960746,0.0005186055,0.0003841185,0.0003073862,0.000005680542,0.00004213246,0.000001920703,0.0009563997],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002561741,"threshold_uncertainty_score":0.008569896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2933848327950401,"score_gpt":0.4360923121443421,"score_spread":0.142707479349302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}