{"id":"W2017595454","doi":"10.1371/journal.pone.0040690","title":"Mitochondrial Respiration - An Important Therapeutic Target in Melanoma","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; National Cancer Institute; University of Pittsburgh; Pennsylvania Department of Health","keywords":"Melanoma; Stable isotope labeling by amino acids in cell culture; Oxidative phosphorylation; Cancer research; Glycolysis; Biology; Mitochondrion; Bioenergetics; Oxidative stress; Cancer cell; Cancer; Cell biology; Biochemistry; Proteomics; Metabolism; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513993,0.00009852819,0.0001355686,0.00003796901,0.00002973088,0.00001254481,0.00009049313,0.0001169751,0.00005694197],"category_scores_gemma":[0.00003519585,0.00009536672,0.00003606596,0.0000583707,0.00002228521,0.00001088338,0.00002417184,0.00006877739,0.00001022783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001078577,"about_ca_system_score_gemma":0.00004640249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003861738,"about_ca_topic_score_gemma":0.0001178572,"domain_scores_codex":[0.9991863,0.00005950113,0.0001846284,0.0001865103,0.000136571,0.0002464698],"domain_scores_gemma":[0.9995423,0.000003495443,0.00005787234,0.0002762929,0.00003162701,0.00008842494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001175479,0.0006148901,0.0151231,0.000008247615,0.00004480568,2.42773e-7,0.0001044621,0.000001207747,0.9829839,0.000110062,0.0001651894,0.0007262864],"study_design_scores_gemma":[0.001027697,0.0003122523,0.02692105,0.00001289672,0.00006165441,0.000002502969,0.00003500815,0.00004870216,0.9038916,0.0001579281,0.06728453,0.0002441676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923365,0.006352246,0.00008629159,0.00006257095,0.0004668451,0.000207161,0.00001319932,0.00001032675,0.0004649059],"genre_scores_gemma":[0.9918981,0.0004182958,0.00183001,0.0003866934,0.004877649,0.0000523126,0.0001429646,0.00002209485,0.0003719211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07909235,"threshold_uncertainty_score":0.3888942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03269168858868903,"score_gpt":0.2530380317729768,"score_spread":0.2203463431842878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}