{"id":"W2017608841","doi":"10.1074/jbc.m513628200","title":"A Phage Display Screen and Binding Studies with Acetylated Low Density Lipoprotein Provide Evidence for the Importance of the Scavenger Receptor Cysteine-rich (SRCR) Domain in the Ligand-binding Function of MARCO","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Scavenger receptor; Cysteine; Scavenger; Phage display; Function (biology); Ligand (biochemistry); Low-density lipoprotein; Acetylation; Lipoprotein; Chemistry; Binding domain; Domain (mathematical analysis); Receptor; Biochemistry; Biology; Binding site; Cell biology; Cholesterol; Mathematics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002683651,0.0004730266,0.0006374652,0.0004995998,0.0003095129,0.000291229,0.0003248329,0.0004024248,0.001146198],"category_scores_gemma":[0.0005952516,0.0001206545,0.0004787637,0.0005836447,0.0001775326,0.0001721237,0.0002094457,0.0003800887,0.0007621138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001420456,"about_ca_system_score_gemma":0.0002120574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00089457,"about_ca_topic_score_gemma":0.001078787,"domain_scores_codex":[0.9997308,0.00003148724,0.00002438263,0.00005442806,0.0001093531,0.00004950805],"domain_scores_gemma":[0.9996315,0.0001815087,0.00004778381,0.00003092039,0.00005551034,0.00005276697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009310821,0.00005133472,0.001166885,0.00005286298,0.00001087344,0.000394083,0.00004845551,0.00004393543,0.9953661,0.00004342609,0.00004167473,0.002687137],"study_design_scores_gemma":[0.00001989,0.0007578476,0.04154852,0.00001670847,0.0001124522,0.00309305,0.0001227211,0.002161991,0.9465023,0.0001075764,0.005525086,0.00003186766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812075,0.001052729,0.01268801,0.0001324369,0.00003349749,0.0001535606,0.001795803,0.0001908636,0.002745642],"genre_scores_gemma":[0.960485,0.001164821,0.02327179,0.0002100566,0.00001838252,0.0001127212,0.009144737,0.00007285288,0.005519557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146198,"threshold_uncertainty_score":0.003834426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04348554708250046,"score_gpt":0.302128661353672,"score_spread":0.2586431142711715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}