{"id":"W2017622605","doi":"10.1002/stem.1128","title":"Targeting p90 Ribosomal S6 Kinase Eliminates Tumor-Initiating Cells by Inactivating Y-Box Binding Protein-1 in Triple-Negative Breast Cancers","year":2012,"lang":"en","type":"article","venue":"Stem Cells","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Cancer Research Trust New Zealand; Cancer Society of New Zealand; Canadian Institutes of Health Research; Cancer Research Society; National Institute for Health and Care Research; Child and Family Research Institute; Stand Up To Cancer; Breast Cancer Research Trust; American Association for Cancer Research","keywords":"CD44; Biology; Cancer research; Gene silencing; Triple-negative breast cancer; Molecular biology; Ribosomal s6 kinase; Kinase; Breast cancer; Cancer; Cell; P70-S6 Kinase 1; Cell biology; Protein kinase B; Phosphorylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009268926,0.0004768667,0.0007565193,0.0002847756,0.0002392199,0.00006182324,0.0001639662,0.0001337273,0.0003067456],"category_scores_gemma":[0.00007444949,0.0004541395,0.0001703038,0.0007263291,0.00009932856,0.0005863692,0.0001216789,0.0006475511,0.00007661049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00116966,"about_ca_system_score_gemma":0.0002897909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001410378,"about_ca_topic_score_gemma":0.00003168872,"domain_scores_codex":[0.9966133,0.0002146631,0.0008017552,0.0005781883,0.0005221129,0.001269948],"domain_scores_gemma":[0.9983245,0.0002796114,0.0005439928,0.0002912334,0.0001348754,0.0004257713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002465322,0.0001926445,0.004956418,0.0005774202,0.00007280005,0.00007484665,0.001895352,0.00002962807,0.9821388,0.00002213699,0.0009959063,0.008797544],"study_design_scores_gemma":[0.002633361,0.0001733093,0.0001838916,0.001047062,0.00009432923,0.00003963971,0.01003841,0.0001467852,0.9835925,0.000003603877,0.001548101,0.0004990738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930741,0.0009512889,0.00007681995,0.0001409689,0.0006890456,0.00156998,0.0002783545,0.00009694718,0.003122553],"genre_scores_gemma":[0.9946859,0.00004947181,0.002874526,0.0002041458,0.0005162637,0.0001862775,0.00004067674,0.0001048984,0.001337783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008298471,"threshold_uncertainty_score":0.999791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480897866674547,"score_gpt":0.2515502230569489,"score_spread":0.2367412443902034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}