{"id":"W2017622605","doi":"10.1002/stem.1128","title":"Targeting p90 Ribosomal S6 Kinase Eliminates Tumor-Initiating Cells by Inactivating Y-Box Binding Protein-1 in Triple-Negative Breast Cancers","year":2012,"lang":"en","type":"article","venue":"Stem Cells","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Cancer Research Trust New Zealand; Cancer Society of New Zealand; Canadian Institutes of Health Research; Cancer Research Society; National Institute for Health and Care Research; Child and Family Research Institute; Stand Up To Cancer; Breast Cancer Research Trust; American Association for Cancer Research","keywords":"CD44; Biology; Cancer research; Gene silencing; Triple-negative breast cancer; Molecular biology; Ribosomal s6 kinase; Kinase; Breast cancer; Cancer; Cell; P70-S6 Kinase 1; Cell biology; Protein kinase B; Phosphorylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638022,0.0004263377,0.000468237,0.0001903634,0.0001260941,0.0003424604,0.0002362299,0.0002286551,0.0009643684],"category_scores_gemma":[0.00007955503,0.0002035684,0.0002822038,0.0001508504,0.0002101755,0.0001538714,0.0001640651,0.0006502015,0.0005114497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002842081,"about_ca_system_score_gemma":0.0002856677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007451231,"about_ca_topic_score_gemma":0.001295125,"domain_scores_codex":[0.999872,0.00001550874,0.00001616679,0.00002386779,0.00003995913,0.00003247539],"domain_scores_gemma":[0.9999374,0.000009046072,0.00001564817,0.000008098948,0.000005171677,0.00002464793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008253221,0.00003833199,0.00007475801,0.00002636344,0.000005294031,0.00002966859,0.000008783377,0.00007172574,0.9984401,0.00008090256,0.00006481983,0.001076938],"study_design_scores_gemma":[0.00002420562,0.0003869263,0.001599174,0.000003356046,0.00001621301,0.0002197706,0.00001558756,0.001145199,0.9942021,0.0000295795,0.002354222,0.000003740621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937387,0.00153632,0.002188529,0.0001438198,0.00005216755,0.00004801919,0.0003919487,0.0002236229,0.001676958],"genre_scores_gemma":[0.9939857,0.0009836376,0.001753626,0.00005434429,0.000007870631,0.00004179241,0.0005269697,0.00003805841,0.002608018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009643684,"threshold_uncertainty_score":0.003226161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480897866674547,"score_gpt":0.2515502230569489,"score_spread":0.2367412443902034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}