{"id":"W2017625220","doi":"10.1016/j.bmc.2007.11.006","title":"5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Piperacillin; Beta-Lactamase Inhibitors; Broad spectrum; In vivo; Sulbactam; Clavulanic acid; Pyrazole; Imidazole; Stereochemistry; Combinatorial chemistry; Structure–activity relationship; Enzyme; In vitro; Antibiotics; Bacteria; Biochemistry; Antibiotic resistance; Imipenem; Biology; Amoxicillin; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004814633,0.0002971755,0.0003586555,0.00005343817,0.00008965849,0.00002301018,0.0002924606,0.0003209604,0.00018945],"category_scores_gemma":[0.000441382,0.0002854708,0.00009542365,0.0001984582,0.0003992715,0.000009294228,0.000190573,0.0001969145,0.000006488094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000437757,"about_ca_system_score_gemma":0.0001559512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001036187,"about_ca_topic_score_gemma":0.0000197369,"domain_scores_codex":[0.9981222,0.00001921026,0.0005442827,0.0005212833,0.0003381559,0.000454893],"domain_scores_gemma":[0.9988784,0.00006499863,0.0002786055,0.0004591038,0.00007755419,0.0002413093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002274261,0.0000731421,0.01955418,0.000152291,0.00006104473,0.00002493425,0.00006098371,3.919824e-7,0.9783527,0.000009815204,0.0004181025,0.001064968],"study_design_scores_gemma":[0.0007428104,0.0001304732,0.03377893,0.0001311014,0.00005412562,0.0001212054,0.0007502193,0.00000250425,0.9619086,0.00004162281,0.00205965,0.0002787677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941671,0.00295792,0.0001873771,0.0001699527,0.0001618905,0.0001307515,0.00001167137,0.00002911635,0.002184208],"genre_scores_gemma":[0.997844,0.0005041683,0.0002387164,0.00008516934,0.0006908803,0.000001757938,0.00005504184,0.00004754147,0.0005327413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01644413,"threshold_uncertainty_score":0.9999598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006487268533534182,"score_gpt":0.2444773328667845,"score_spread":0.2379900643332503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}