{"id":"W2017625220","doi":"10.1016/j.bmc.2007.11.006","title":"5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Piperacillin; Beta-Lactamase Inhibitors; Broad spectrum; In vivo; Sulbactam; Clavulanic acid; Pyrazole; Imidazole; Stereochemistry; Combinatorial chemistry; Structure–activity relationship; Enzyme; In vitro; Antibiotics; Bacteria; Biochemistry; Antibiotic resistance; Imipenem; Biology; Amoxicillin; Pseudomonas aeruginosa","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001424536,0.0002512869,0.0003799557,0.0002348898,0.0001224259,0.0002833572,0.0005797744,0.0002556291,0.00129685],"category_scores_gemma":[0.0001431497,0.0001498641,0.0001225746,0.0002571461,0.0001594167,0.000258856,0.0002103032,0.0003350006,0.0003166255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003644525,"about_ca_system_score_gemma":0.0001562281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004790586,"about_ca_topic_score_gemma":0.0007362706,"domain_scores_codex":[0.9999075,0.00001470338,0.000007053577,0.0000121867,0.00001810076,0.00004040992],"domain_scores_gemma":[0.9999629,0.000004893765,0.00001043794,0.000003940769,0.000004401355,0.00001336783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007343721,0.0001331662,0.0002075569,0.0002225833,0.00002179042,0.0004760031,0.00007216586,0.001864298,0.9656354,0.002199502,0.0006653088,0.02776777],"study_design_scores_gemma":[0.0001312096,0.002402784,0.001969393,0.00002307777,0.00004704634,0.0008127227,0.00003489062,0.004317124,0.9779657,0.0001688608,0.01210119,0.0000261026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756448,0.008117368,0.005394109,0.0001595394,0.0001268808,0.00006784194,0.000280341,0.000339472,0.009869584],"genre_scores_gemma":[0.9918267,0.002750671,0.002072215,0.0000544226,0.00001505338,0.00002565721,0.000228571,0.00001384048,0.003013021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129685,"threshold_uncertainty_score":0.004338384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006487268533534182,"score_gpt":0.2444773328667845,"score_spread":0.2379900643332503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}