{"id":"W2017633750","doi":"10.1016/j.chemphyslip.2010.05.185","title":"Key role of the ERK1/2 MAPK pathway in the transcriptional regulation of the stearoyl-CoA desaturase (SCD1) gene expression in response to leptin","year":2010,"lang":"en","type":"article","venue":"Chemistry and Physics of Lipids","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Montréal","funders":"","keywords":"Leptin; Chemistry; Transcription factor; MAPK/ERK pathway; PI3K/AKT/mTOR pathway; Signal transduction; Stearoyl-CoA Desaturase; Internal medicine; Endocrinology; Cell biology; Gene expression; Gene; Biochemistry; Biology; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950972,0.0004068088,0.0002584346,0.0002885327,0.0003136105,0.000372618,0.0001786957,0.0002493697,0.003903442],"category_scores_gemma":[0.000139898,0.0002399311,0.0003361111,0.0001277517,0.0002389799,0.0003729931,0.0003321132,0.0006019937,0.0009265918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002781773,"about_ca_system_score_gemma":0.0003638109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005179208,"about_ca_topic_score_gemma":0.0007478491,"domain_scores_codex":[0.9998814,0.00001997846,0.000009806861,0.00002308536,0.00002116469,0.00004457949],"domain_scores_gemma":[0.9999259,0.00001273011,0.00001127555,0.000009015437,0.00001489623,0.00002611802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001701605,0.00009640686,0.0003891842,0.000106434,0.00001080998,0.0001556169,0.0000368749,0.0002069281,0.9911662,0.001058519,0.0002317339,0.004839817],"study_design_scores_gemma":[0.0002452887,0.0004581777,0.06752718,0.00005057587,0.00006691197,0.001047589,0.0002277196,0.004960992,0.911277,0.00205947,0.01204621,0.00003288825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706178,0.008779419,0.007381971,0.001238555,0.0002010313,0.00007893873,0.001520855,0.0001580221,0.01002346],"genre_scores_gemma":[0.9831924,0.002928457,0.002571195,0.0001588505,0.00005432096,0.0000652944,0.000966037,0.00003291717,0.01003056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003903442,"threshold_uncertainty_score":0.01305836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005520999515234173,"score_gpt":0.2107665058061407,"score_spread":0.2052455062909065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}