{"id":"W2017687056","doi":"10.1021/acs.jafc.5b00882","title":"Synthesis, Biological Activity, and Conformational Study of N-Methylated Allatostatin Analogues Inhibiting Juvenile Hormone Biosynthesis","year":2015,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ministry of Science and Technology of the People's Republic of China; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Juvenile hormone; Biosynthesis; Chemistry; Stereochemistry; Biochemistry; Biological activity; Hormone; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002609371,0.0001466422,0.0003423641,0.00002060949,0.00004542933,0.00002696773,0.00009520689,0.0001298026,0.000005664641],"category_scores_gemma":[0.0003210322,0.00008653526,0.0000959859,0.00009081709,0.00007823941,0.00001506063,0.00009908292,0.000109183,1.58876e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001035287,"about_ca_system_score_gemma":0.00002235252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001013342,"about_ca_topic_score_gemma":0.000003080281,"domain_scores_codex":[0.9990996,0.00004523618,0.0004006612,0.0001469989,0.0001863871,0.0001211128],"domain_scores_gemma":[0.9990584,0.00007196525,0.0004316036,0.00006090718,0.0002237094,0.0001533987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000764727,0.0001985529,0.001812696,0.00001930248,0.0002443753,0.000001081858,0.0001170099,0.000008324634,0.9958403,0.000001191906,0.0001439532,0.001536795],"study_design_scores_gemma":[0.000548573,0.0006149204,0.02777112,0.00002996751,0.0001027343,0.0001075292,0.003662641,0.000006773004,0.9669292,0.0000236509,0.00005828635,0.0001446166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984067,0.001213,0.000006453946,0.0001171622,0.000008059545,0.00004209824,0.00002367648,0.000003054071,0.000179771],"genre_scores_gemma":[0.9994847,0.000219857,0.0001386511,0.000007773822,0.0001159347,0.000002025266,0.00001318522,0.000003979067,0.00001394871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02891105,"threshold_uncertainty_score":0.3528805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824472065866488,"score_gpt":0.2258928619577256,"score_spread":0.2076481412990607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}