{"id":"W2017711940","doi":"10.1371/journal.pgen.1003804","title":"Identification of 526 Conserved Metazoan Genetic Innovations Exposes a New Role for Cofactor E-like in Neuronal Microtubule Homeostasis","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Neurological Disorders and Stroke; Natural Sciences and Engineering Research Council of Canada; Genome Canada; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC","keywords":"Biology; Multicellular organism; Caenorhabditis elegans; Gene; Model organism; Microtubule; Interactome; Flatworm; Genetics; Conserved sequence; Cell biology; Computational biology; Evolutionary biology; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002190808,0.0004331797,0.0006284227,0.002024431,0.0007263234,0.0006504392,0.0002472694,0.0003771429,0.002942604],"category_scores_gemma":[0.0007763714,0.0001979634,0.000666151,0.003058983,0.0002683352,0.0003930844,0.0006028268,0.0005287346,0.001605572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003368908,"about_ca_system_score_gemma":0.0005076462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002713415,"about_ca_topic_score_gemma":0.00743184,"domain_scores_codex":[0.9996439,0.0000213459,0.00002444113,0.0001763081,0.00007407583,0.00005981431],"domain_scores_gemma":[0.9996966,0.00007963649,0.0000620377,0.00008489161,0.00003860596,0.00003818611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00130533,0.0001877239,0.2388028,0.002337037,0.0004969867,0.001024551,0.0003835471,0.005479559,0.6185676,0.002666738,0.01547469,0.1132734],"study_design_scores_gemma":[0.00006270275,0.0001442388,0.7899839,0.0001623505,0.0003370721,0.001628007,0.0003662079,0.00874133,0.06308847,0.001806508,0.1336163,0.00006283762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.864957,0.004010805,0.007334985,0.0001963577,0.00003822989,0.00003990526,0.1154098,0.001232182,0.006780754],"genre_scores_gemma":[0.7558174,0.002195779,0.01761158,0.0002595151,0.00001732369,0.00009905409,0.2211903,0.0002703391,0.002538817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002942604,"threshold_uncertainty_score":0.009843946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02072026626391737,"score_gpt":0.2352155340157875,"score_spread":0.2144952677518701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}