{"id":"W2017713458","doi":"10.1186/1471-213x-10-72","title":"Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature","year":2010,"lang":"en","type":"article","venue":"BMC Developmental Biology","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada; Susan G. Komen for the Cure","keywords":"Biology; Lymphangiogenesis; Reprogramming; Lymphatic Endothelium; Lymphatic system; Embryonic stem cell; Cell biology; Vascular endothelial growth factor C; Endothelial stem cell; Pathology; Immunology; Vascular endothelial growth factor A; Cancer research; Genetics; Gene; Vascular endothelial growth factor; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002618346,0.0002796702,0.000152675,0.000280335,0.000155189,0.00041022,0.0002749869,0.0004416504,0.002230602],"category_scores_gemma":[0.0002020362,0.0002319917,0.0002437078,0.0001690836,0.0002906883,0.000243554,0.0003194968,0.0006818215,0.0006567173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002406383,"about_ca_system_score_gemma":0.000174796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000229215,"about_ca_topic_score_gemma":0.0004525453,"domain_scores_codex":[0.9997711,0.00002456632,0.00002077838,0.0000478495,0.00009357343,0.00004219165],"domain_scores_gemma":[0.9997657,0.00004248695,0.0000934545,0.00003393868,0.00002525384,0.00003917341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000042922,0.000009263414,0.0001972615,0.00004146648,0.000004255649,0.00007327898,0.00002311382,0.0001272099,0.9964622,0.0006526717,0.00007860997,0.002287841],"study_design_scores_gemma":[0.00001349766,0.0001236237,0.003107984,0.00001102857,0.00001941307,0.0004671492,0.00002424751,0.0006692841,0.9852982,0.0001610015,0.01009823,0.000006398979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540227,0.001766927,0.03608688,0.0002613362,0.0001134737,0.00007417651,0.001853622,0.0007782455,0.005042581],"genre_scores_gemma":[0.9685311,0.00162177,0.01397588,0.0001360904,0.00002180682,0.0000902758,0.001956157,0.0001772447,0.01348958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002230602,"threshold_uncertainty_score":0.007462144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314057527916933,"score_gpt":0.2541393477180859,"score_spread":0.2409987724389166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}