{"id":"W2017723320","doi":"10.1074/jbc.m107412200","title":"Dissecting the Chemistry of Nicotinic Receptor-Ligand Interactions with Infrared Difference Spectroscopy","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Chemistry; Hydrogen bond; Ligand (biochemistry); Stereochemistry; Agonist; Infrared spectroscopy; Receptor; Nicotinic agonist; Crystallography; Molecule; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458632,0.0002308308,0.0003571391,0.00001139281,0.00009596052,0.0000226661,0.0005280278,0.0001911719,0.0004755655],"category_scores_gemma":[0.0007234683,0.0001294095,0.0002162582,0.0001513607,0.0002811406,0.000006473024,0.0001475163,0.0005568762,0.000003166841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003283198,"about_ca_system_score_gemma":0.00004549704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001455073,"about_ca_topic_score_gemma":7.513516e-7,"domain_scores_codex":[0.998603,0.00004619884,0.0006121222,0.0002598377,0.0002137205,0.0002650948],"domain_scores_gemma":[0.9983281,0.0001196466,0.0007795793,0.0003514827,0.0003031264,0.0001180263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001656682,0.0002457814,0.0129932,0.00002649382,0.0001317205,9.520427e-7,0.00005052433,0.0000099491,0.9849724,9.500233e-7,0.001150165,0.0002522551],"study_design_scores_gemma":[0.0006241595,0.0003696244,0.0008953716,0.00007319937,0.00003386649,0.0002142391,0.0004604089,0.00001416669,0.993085,0.00001988522,0.004043266,0.0001668632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943156,0.0009165241,0.0001747899,0.0001946918,0.0001250555,0.00007952829,0.0000117035,0.000007953428,0.004174151],"genre_scores_gemma":[0.9960328,0.0005594777,0.0006130367,0.00004210096,0.0007419226,0.000005261369,0.00001283105,0.00001611216,0.001976491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01209783,"threshold_uncertainty_score":0.5277166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946672060016242,"score_gpt":0.2642202426349516,"score_spread":0.2447535220347892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}