{"id":"W2017765270","doi":"10.1016/j.freeradbiomed.2006.08.015","title":"Protection by EGb 761 against β-amyloid-induced neurotoxicity: Involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation","year":2006,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Neurotoxicity; Chemistry; Amyloid β; Amyloid fibril; Amyloid (mycology); NF-κB; Cell biology; Fibril; Neuroscience; Biochemistry; Signal transduction; Toxicity; Medicine; Biology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002578709,0.0001626113,0.0004158542,0.0001525996,0.0001192305,0.000002567923,0.00002992356,0.0001822438,0.00001743413],"category_scores_gemma":[0.0001602392,0.0001145884,0.00003214797,0.0001256956,0.0006491565,0.00008042031,0.00006566537,0.0001691949,5.653757e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002827105,"about_ca_system_score_gemma":0.0000458088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003619941,"about_ca_topic_score_gemma":0.00002825266,"domain_scores_codex":[0.9988105,0.0001079347,0.0003937077,0.0002571339,0.0002075619,0.0002232193],"domain_scores_gemma":[0.9992965,0.00007689869,0.0001542828,0.0001596787,0.00007601759,0.0002366333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008175673,0.0004251451,0.01593066,0.0005637505,0.0003808367,0.00002732539,0.0001835631,1.312321e-7,0.9635229,0.0006607039,0.001100364,0.01638709],"study_design_scores_gemma":[0.02791687,0.01628572,0.0776795,0.001322,0.0007993584,0.0001701571,0.0003972217,0.0009388191,0.8626228,0.009328008,0.002160342,0.0003792251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907381,0.005936019,0.0002391853,0.001728954,0.00003521664,0.0009717137,0.0001023291,0.00002377372,0.0002247146],"genre_scores_gemma":[0.9978385,0.001192581,0.00006679761,0.0002352701,0.0001167037,0.00005654538,0.0004781701,0.000008957528,0.000006492459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1009001,"threshold_uncertainty_score":0.4672781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02968597556374255,"score_gpt":0.2766886518846213,"score_spread":0.2470026763208788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}