{"id":"W2017789699","doi":"10.1006/abbi.2000.1923","title":"The Presence of an Aqueous Cavity in the Proton-Pumping Pathway of the Pyridine Nucleotide Transhydrogenase of Escherichia coli Is Suggested by the Reaction of the Enzyme with Sulfhydryl Inhibitors","year":2000,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council","keywords":"Chemistry; Transmembrane domain; Stereochemistry; Enzyme; Transmembrane protein; Cysteine; NAD+ kinase; Escherichia coli; Helix (gastropod); Residue (chemistry); Active site; Flavin group; Biochemistry; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001644597,0.0001747919,0.0002004356,0.000004993949,0.0001172122,0.000007012694,0.0006361413,0.00008912513,0.000001523469],"category_scores_gemma":[0.00003577946,0.00007928701,0.0001419916,0.0001936531,0.001459741,0.000008087302,0.00008357687,0.0001832632,2.334169e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003211597,"about_ca_system_score_gemma":0.00009712829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001429038,"about_ca_topic_score_gemma":0.00001516424,"domain_scores_codex":[0.9989046,0.0001115181,0.0003608015,0.0002321528,0.0002284309,0.0001625118],"domain_scores_gemma":[0.9986882,0.00009774258,0.0003867808,0.0007497282,0.00004733654,0.00003024755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003910442,0.0002309207,0.0005159283,0.0002186865,0.00005341019,3.017829e-7,0.0006748669,0.00002398803,0.9957388,0.000007474835,0.00001901162,0.002125582],"study_design_scores_gemma":[0.0003754862,0.0001617586,0.001037091,0.0001348962,0.00003822693,0.000006652607,0.0005924635,0.0001273536,0.9971151,0.00009003215,0.000224894,0.00009602275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985482,0.0002854492,0.000002309572,0.0002474983,0.00001286004,0.0003919731,0.000181323,0.000002150341,0.0003282289],"genre_scores_gemma":[0.9995288,0.0002678729,0.00001604359,0.00003261968,0.00003615617,0.00001911997,0.00002179731,0.00001177826,0.00006577805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002029559,"threshold_uncertainty_score":0.5378478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003225789774611118,"score_gpt":0.1907847785808121,"score_spread":0.187558988806201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}