{"id":"W2017789699","doi":"10.1006/abbi.2000.1923","title":"The Presence of an Aqueous Cavity in the Proton-Pumping Pathway of the Pyridine Nucleotide Transhydrogenase of Escherichia coli Is Suggested by the Reaction of the Enzyme with Sulfhydryl Inhibitors","year":2000,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council","keywords":"Chemistry; Transmembrane domain; Stereochemistry; Enzyme; Transmembrane protein; Cysteine; NAD+ kinase; Escherichia coli; Helix (gastropod); Residue (chemistry); Active site; Flavin group; Biochemistry; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004183121,0.0003345608,0.0003154249,0.0001565142,0.0006182138,0.0007396985,0.0005935373,0.0007882854,0.0006984031],"category_scores_gemma":[0.0006551816,0.0002691931,0.0002562348,0.0001106479,0.001291451,0.00130271,0.0006735804,0.0005493315,0.0002494945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002326458,"about_ca_system_score_gemma":0.0004848551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002153876,"about_ca_topic_score_gemma":0.0002095454,"domain_scores_codex":[0.9998671,0.00003266701,0.00001027582,0.00003392477,0.00002678674,0.00002928204],"domain_scores_gemma":[0.9995783,0.0001408696,0.00009229215,0.0000517518,0.00003850543,0.00009829621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008639547,0.00003904118,0.001185214,0.0001742525,0.00001354838,0.0009843695,0.0001739417,0.00082351,0.982354,0.008586099,0.00009315129,0.004708802],"study_design_scores_gemma":[0.00009756154,0.0007673359,0.001877168,0.00001651796,0.00003102702,0.0009501454,0.0002134066,0.006237966,0.9816532,0.00528613,0.00283472,0.00003479344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698074,0.000864726,0.02675623,0.0005318201,0.0000690376,0.00003226723,0.00007278228,0.0002328728,0.001632862],"genre_scores_gemma":[0.9938111,0.0002055222,0.005522225,0.00003652304,0.00001381121,0.0000143035,0.00004376491,0.000009131029,0.0003435975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007882854,"threshold_uncertainty_score":0.002336442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003225789774611118,"score_gpt":0.1907847785808121,"score_spread":0.187558988806201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}