{"id":"W2017862071","doi":"10.1016/j.neurobiolaging.2015.02.021","title":"Overexpression of the vesicular acetylcholine transporter enhances dendritic complexity of adult-born hippocampal neurons and improves acquisition of spatial memory during aging","year":2015,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Vesicular acetylcholine transporter; Hippocampal formation; Neuroscience; Hippocampus; Cholinergic; Neurogenesis; Morris water navigation task; Acetylcholine; Cholinergic neuron; Biology; Choline acetyltransferase; Psychology; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690775,0.0003820077,0.0006712558,0.0003259749,0.0001709468,0.0004171513,0.0003502643,0.0004133185,0.0009167665],"category_scores_gemma":[0.0001522418,0.0002456171,0.0003661092,0.0001976077,0.0004148386,0.0005204781,0.0002966642,0.0007415306,0.0002281744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004694175,"about_ca_system_score_gemma":0.0003364752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001298166,"about_ca_topic_score_gemma":0.002318477,"domain_scores_codex":[0.9998245,0.00001617426,0.00002492757,0.00004242309,0.00003176,0.00006036573],"domain_scores_gemma":[0.9997413,0.000017839,0.00008832828,0.00002852911,0.00003123154,0.00009283618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006206685,0.00007452427,0.0002778925,0.00003167049,0.00001497844,0.00004716338,0.00002549355,0.0000499009,0.9971567,0.0001016741,0.00004306011,0.001556398],"study_design_scores_gemma":[0.00006966456,0.0008864431,0.01218251,0.00001025896,0.0000856807,0.0001753339,0.0001003252,0.001015725,0.9843355,0.0001764302,0.0009499455,0.00001210982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981341,0.000645989,0.0007011964,0.0000646787,0.00002969119,0.000006346119,0.0001250467,0.00006421926,0.0002286353],"genre_scores_gemma":[0.9967705,0.0005746335,0.0007279159,0.00003128554,0.00001088267,0.00001818542,0.0001655152,0.00002520631,0.001675878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298166,"threshold_uncertainty_score":0.003405869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02689813910426546,"score_gpt":0.2485308926511857,"score_spread":0.2216327535469202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}