{"id":"W2017868263","doi":"10.1128/aac.00594-10","title":"A <i>mec</i> <i>A</i> -Negative Strain of Methicillin-Resistant <i>S</i> <i>taphylococcus</i> <i>aureus</i> with High-Level β-Lactam Resistance Contains Mutations in Three Genes","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Johnson and Johnson Pharmaceutical Research and Development; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of California, San Francisco","keywords":"Cefoxitin; Efflux; Penicillin binding proteins; Staphylococcus aureus; Strain (injury); Biology; Gene; Microbiology; Genetics; Penicillin; Antibiotics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004755821,0.0006947307,0.001226949,0.0003012859,0.0002357526,0.000080415,0.0003723535,0.0004133303,0.0001209449],"category_scores_gemma":[0.00009070234,0.0005835567,0.0002323811,0.0009026661,0.001224899,0.0002452733,0.00006980306,0.0009167237,0.000006265311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007386949,"about_ca_system_score_gemma":0.0004286636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007035008,"about_ca_topic_score_gemma":0.01483601,"domain_scores_codex":[0.9965776,0.00008411983,0.001026869,0.0009562997,0.0005487857,0.0008063274],"domain_scores_gemma":[0.997582,0.0003146316,0.0005664282,0.0007674658,0.0004862316,0.0002832267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00350626,0.0008146224,0.02450882,0.0003559395,0.0002826301,0.0001285109,0.0009255366,0.00001426408,0.9620467,0.001573587,0.00448098,0.001362162],"study_design_scores_gemma":[0.01986609,0.0007921308,0.1575504,0.001357175,0.0003803638,0.00004722405,0.0006171782,0.00003134017,0.7784039,0.001880239,0.03757285,0.001501049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889815,0.0001019873,0.001056441,0.005456211,0.0001873507,0.001586317,0.001294735,0.00008550615,0.001249883],"genre_scores_gemma":[0.9691184,0.0006287944,0.01983137,0.009378582,0.0001483257,0.00005431822,0.0001209226,0.0001384768,0.0005807768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1836428,"threshold_uncertainty_score":0.9996616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740149156625402,"score_gpt":0.2636300473619125,"score_spread":0.2462285557956585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}