{"id":"W2017868263","doi":"10.1128/aac.00594-10","title":"A <i>mec</i> <i>A</i> -Negative Strain of Methicillin-Resistant <i>S</i> <i>taphylococcus</i> <i>aureus</i> with High-Level β-Lactam Resistance Contains Mutations in Three Genes","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Johnson and Johnson Pharmaceutical Research and Development; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of California, San Francisco","keywords":"Cefoxitin; Efflux; Penicillin binding proteins; Staphylococcus aureus; Strain (injury); Biology; Gene; Microbiology; Genetics; Penicillin; Antibiotics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307386,0.0004645187,0.0002586135,0.00029377,0.0001728792,0.0002554746,0.0003567096,0.0002971585,0.001891843],"category_scores_gemma":[0.0003311441,0.0001758381,0.0003645086,0.0002182487,0.0002714381,0.0001223946,0.0002320888,0.00050316,0.0008734983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002226893,"about_ca_system_score_gemma":0.0002769352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002636051,"about_ca_topic_score_gemma":0.002466889,"domain_scores_codex":[0.9997672,0.00003342145,0.00003130171,0.00005458902,0.00007409203,0.00003924699],"domain_scores_gemma":[0.9997852,0.00003968724,0.00005525109,0.0000450994,0.00003082929,0.00004382624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008471318,0.00005453638,0.000622932,0.00001634456,0.000006297375,0.0001437522,0.00001753134,0.00002641975,0.9980245,0.00008828852,0.0001031731,0.0008116484],"study_design_scores_gemma":[0.00005453756,0.001033811,0.03016063,0.00001690623,0.00004821049,0.005089664,0.0001079512,0.001155241,0.9557194,0.00008774388,0.006500294,0.00002569304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921066,0.0002424192,0.002838993,0.0002054575,0.00006232576,0.0001623518,0.001798063,0.00008113692,0.00250273],"genre_scores_gemma":[0.9793367,0.0002488732,0.009358518,0.0001248914,0.00002511795,0.00008300178,0.005452911,0.00008967924,0.005280356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002636051,"threshold_uncertainty_score":0.006328881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01740149156625402,"score_gpt":0.2636300473619125,"score_spread":0.2462285557956585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}