{"id":"W2017878096","doi":"10.1016/j.clim.2011.02.005","title":"Abrogation of pathogenic IgG autoantibody production in CD40L gene-deleted lupus-prone New Zealand Black mice","year":2011,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Mount Sinai Hospital; University of Toronto; Arthritis Research Centre of Canada","funders":"Canadian Institutes of Health Research; Arthritis Society","keywords":"Autoantibody; CD40; Germinal center; Systemic lupus erythematosus; Immunoglobulin class switching; Biology; Immunology; B cell; Immune system; Autoimmune disease; Antibody; In vitro; Medicine; Disease; Internal medicine; Genetics; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004880818,0.001446818,0.0008338431,0.001751509,0.000506626,0.0007091704,0.0007069306,0.001322479,0.003142833],"category_scores_gemma":[0.0004502776,0.0005629433,0.0005752101,0.0003766645,0.001129758,0.0005344062,0.0004960586,0.002088835,0.0009228135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005344539,"about_ca_system_score_gemma":0.0004906361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212577,"about_ca_topic_score_gemma":0.001762297,"domain_scores_codex":[0.9992703,0.0001107089,0.00007907501,0.0001659374,0.0002035884,0.0001703603],"domain_scores_gemma":[0.9987267,0.000162474,0.0005370327,0.0001169448,0.00008485358,0.0003719892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003664652,0.0001299665,0.00009982583,0.00003145212,0.000007147547,0.0001563469,0.00004011367,0.00005232947,0.9980605,0.0002365706,0.0000527326,0.0007666346],"study_design_scores_gemma":[0.0003135081,0.001316618,0.003850402,0.00002399282,0.00005915684,0.0009690152,0.00008905732,0.001002552,0.9898087,0.0002349864,0.002309008,0.00002301368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917501,0.000622154,0.00351401,0.000416187,0.0001002828,0.00008951882,0.0006731427,0.0004393146,0.002395211],"genre_scores_gemma":[0.9823735,0.0008886644,0.004669227,0.000179118,0.00006341639,0.0001759128,0.0005233863,0.000213142,0.01091363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003142833,"threshold_uncertainty_score":0.01051384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04011644514864442,"score_gpt":0.2880619124628426,"score_spread":0.2479454673141982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}