{"id":"W2017886758","doi":"10.1126/science.1202142","title":"Real-Time Observation of Transcription Initiation and Elongation on an Endogenous Yeast Gene","year":2011,"lang":"en","type":"article","venue":"Science","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":723,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; Howard Hughes Medical Institute","keywords":"Yeast; Elongation; Gene; Transcription (linguistics); Gene expression; Biology; Endogeny; Transcription factor; TAF4; Genetics; Saccharomyces cerevisiae; Elongation factor; Cell biology; Promoter; RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001703317,0.0001313843,0.0001236512,0.0003386729,0.0001408953,0.0001980484,0.0003017868,0.000176573,0.0004553665],"category_scores_gemma":[0.0004338093,0.00008350256,0.00009483257,0.0002801931,0.000303041,0.0002220187,0.0001388388,0.0003817239,0.0001120918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003741282,"about_ca_system_score_gemma":0.0001227564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007789228,"about_ca_topic_score_gemma":0.00110526,"domain_scores_codex":[0.9998651,0.00001734008,0.000004050766,0.00004070277,0.00005671688,0.00001610372],"domain_scores_gemma":[0.9996984,0.0001386167,0.00005149368,0.00002833564,0.00003791388,0.00004533562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001249536,0.00001395307,0.001975464,0.00002007239,0.000007801893,0.0000376586,0.00003349729,0.0009811915,0.9907662,0.0005307163,0.00005972061,0.005448782],"study_design_scores_gemma":[0.0000124903,0.0001355462,0.01647931,0.000004612896,0.0000155309,0.000184353,0.00003456961,0.05187311,0.9297062,0.0005737913,0.0009609206,0.00001951622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445745,0.0002997128,0.05360249,0.00006090626,0.0000151729,0.00001151414,0.0002791532,0.0002338163,0.0009226396],"genre_scores_gemma":[0.982523,0.0001771848,0.01666794,0.00002167445,0.000007884284,0.00002576007,0.0001316638,0.0000227941,0.0004222704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007789228,"threshold_uncertainty_score":0.002714455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03997113628275893,"score_gpt":0.2352241977031899,"score_spread":0.195253061420431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}