{"id":"W2017887262","doi":"10.1016/j.bmc.2008.06.021","title":"Functionalized pyrrolidine inhibitors of human type II α-mannosidases as anti-cancer agents: Optimizing the fit to the active site","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"National Center for Research Resources; Division of Materials Research; National Institutes of Health; National Science Foundation","keywords":"Pyrrolidine; Chemistry; Golgi apparatus; Stereochemistry; Active site; Biological activity; Chemical synthesis; Binding site; Biochemistry; Enzyme; In vitro; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001918655,0.0003759254,0.0004474099,0.00002491386,0.000730954,0.00001799284,0.0006076101,0.0002292542,0.02097208],"category_scores_gemma":[0.0004404148,0.0002479902,0.0001996742,0.0004845079,0.0004025464,0.00006754664,0.0002696915,0.0004653557,0.0000387742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001766763,"about_ca_system_score_gemma":0.0002288939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001402655,"about_ca_topic_score_gemma":0.000003636362,"domain_scores_codex":[0.9978719,0.0000232603,0.0005166953,0.0004993384,0.0006845917,0.0004042294],"domain_scores_gemma":[0.9983146,0.0001765924,0.000308513,0.0007387514,0.0002560772,0.0002055218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001647986,0.0001240633,0.0003766269,0.0001635092,0.0001910505,0.00002582813,0.001292802,0.00004429105,0.9867275,0.000001782098,0.01068478,0.0002029528],"study_design_scores_gemma":[0.0005674268,0.00003300906,0.0002764269,0.0002549457,0.0001674773,0.0001029758,0.00156728,0.00002229841,0.9781619,0.00000471355,0.01857057,0.0002710083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987316,0.001126572,0.000001552763,0.002134268,0.0001481032,0.0001079681,0.0001012816,0.00007816042,0.008986067],"genre_scores_gemma":[0.9897148,0.0002930944,0.000008520955,0.0004133379,0.001417053,0.0000451066,0.00007157793,0.00004830864,0.007988225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02093331,"threshold_uncertainty_score":0.9999973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04086348797867879,"score_gpt":0.2810257384722104,"score_spread":0.2401622504935316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}